+ |
Ub:E2 | up-regulates activity
ubiquitination
|
TRIM3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271146 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TRIM3 | down-regulates quantity by destabilization
polyubiquitination
|
GKAP1 |
0.25 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271959 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
20352094 |
Here we identify the RING finger-containing protein TRIM3 as a specific E3 ubiquitin ligase for the PSD scaffold GKAP/SAPAP1. Present in PSD fractions from rat brain, TRIM3 stimulates ubiquitination and proteasome-dependent degradation of GKAP, and induces the loss of GKAP and associated scaffold Shank1 from postsynaptic sites. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |