Summary

Name PMPCB
Full Name Mitochondrial-processing peptidase subunit beta
Synonyms Beta-MPP, P-52 | MPPB
Primary ID O75439
Links - -
Type protein
Relations 1
Function Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:29576218) (Probable). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (PubMed:22354088).

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Relations

Regulator Mechanism target score ℹ
+ PMPCBdown-regulates quantity by destabilization img/direct_inhibition.png cleavage PINK1 0.35
Publications: 1 Organism: Homo Sapiens