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Summary
Name
FRAT2
Full Name
GSK-3-binding protein FRAT2
Synonyms
Frequently rearranged in advanced T-cell lymphomas 2, FRAT-2
Primary ID
O75474
Links
-
-
Type
protein
Relations
1
Function
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.
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by mechanism
none
binding
by effect
none
down-regulates activity
by organism:
none
in vitro
by tissue:
none
by cell-line
none
Relations
Regulator
Mechanism
target
score
ℹ
+
FRAT2
down-regulates activity
binding
GSK3B
0.682
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-244030
in vitro
pmid
sentence
11738041
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Publications:
1
Organism:
In Vitro