Summary

Name PSIP1
Full Name PC4 and SFRS1-interacting protein
Synonyms CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52 | DFS70, LEDGF, PSIP2
Primary ID O75475
Links - -
Type protein
Relations 3
Function Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PSIP1 0.344
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage PSIP1 0.355
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png cleavage PSIP1 0.354
Publications: 1 Organism: Homo Sapiens