| + |
Caspase 3 complex | down-regulates quantity by destabilization 
cleavage
|
BRCA1 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256432 |
Asp1155 |
ETPDDLLdDGEIKED |
Homo sapiens |
|
| pmid |
sentence |
| 12149654 |
We demonstrate the cleavage and the consequential downregulation of full-length BRCA1 by caspase-3 during UV-induced apoptosis. Finally, mutation of a caspase-3 specific cleavage site (D/A1154) rendered BRCA1 non-cleavable. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256437 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
PTCH1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256438 |
Asp1405 |
CPGYPETdHGLFEDP |
Homo sapiens |
|
| pmid |
sentence |
| 12907805 |
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
GOLGB1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261235 |
Asp1881 |
LSQISTKdGELKMLQ |
Homo sapiens |
|
| pmid |
sentence |
| 14970262 |
Giantin and syntaxin 5 are cleaved by caspase-3. Given that both giantin and syntaxin 5 are cleaved at an early stage during apoptosis, we anticipated that, at the very least, the delivery of ER-derived transport intermediates to the Golgi would be impaired in apoptotic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates
cleavage
|
IKBKB |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256441 |
Asp242 |
VRQKSEVdIVVSEDL |
Homo sapiens |
|
| pmid |
sentence |
| 11741536 |
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256436 |
Asp373 |
PATQCISdGKLNEGH |
Homo sapiens |
|
| pmid |
sentence |
| 11741536 |
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256435 |
Asp546 |
ALQTDIVdLQRSPMG |
Homo sapiens |
|
| pmid |
sentence |
| 11741536 |
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256434 |
Asp78 |
PNVVAARdVPEGMQN |
Homo sapiens |
|
| pmid |
sentence |
| 11741536 |
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates 
cleavage
|
GAS2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256439 |
Asp278 |
MLQISRVdGKTSPIQ |
Homo sapiens |
|
| pmid |
sentence |
| 10564664 |
We now demonstrate that gas2 is a substrate of caspase-3 but not of caspase-6. Proteolytic processing both in vitro and in vivo is dependent on aspartic residue 279. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
STK4 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256444 |
Asp326 |
NSEEDEMdSGTMVRA |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256445 |
Asp349 |
RVASTMTdGANTMIE |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11517310 |
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
CASP9 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256440 |
Asp330 |
LRTFDQLdAISSLPT |
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 15657060 |
In turn, casp3 directs feedback cleavage of casp9 at asp-330 to generate p37 and p10 subunits. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Active caspase-3 itself is able to process its upstream , caspase-8 and caspase-9, establishing a self-amplifying loop of caspase activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
GSN |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256433 |
Asp403 |
WRDPDQTdGLGLSYL |
Homo sapiens |
|
| pmid |
sentence |
| 9671712 |
We showed that human gelsolin was cleaved during Fas-mediated apoptosis in vivo and that the caspase-3 cleavage site of human gelsolin was at D352 of DQTD352G. gelsolin seems to have dual functions, i.e., it both prevents and, once cleaved, induces cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
IL18 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256378 |
Asp71 |
PLFEDMTdSDCRDNA |
Homo sapiens |
THP-1 Cell |
| pmid |
sentence |
| 9334240 |
We also found two precursor hIL-18 (prohIL-18)-processing activities in the cytosol of THP.1 cells. These activities were blocked separately by the caspase inhibitors Ac-YVAD-CHO and Ac-DEVD-CHO. Further analyses of the partially purified enzymes revealed that one is caspase-1, which cleaves prohIL-18 at the Asp36-Tyr37 site to generate the mature hIL-18, and the other is caspase-3, which cleaves both precursor and mature hIL-18 at Asp71-Ser72 and Asp76-Asn77 to generate biologically inactive products. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256379 |
Asp76 |
MTDSDCRdNAPRTIF |
Homo sapiens |
THP-1 Cell |
| pmid |
sentence |
| 9334240 |
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.|Further analyses of the partially purified enzymes revealed that one is caspase-1, which cleaves prohIL-18 at the Asp36-Tyr37 site to generate the mature hIL-18, and the other is caspase-3, which cleaves both precursor and mature hIL-18 at Asp71-Ser72 and Asp76-Asn77 to generate biologically inactive products. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
AKT |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256446 |
|
|
in vitro |
|
| pmid |
sentence |
| 10579725 |
P53 can inhibit the survival function of integrins by inducing the caspase-dependent cleavage and inactivation of the serine/threonine kinase akt/pkb;the involvement of caspase 3 in akt/pkb regulation was indicated by the ability of z-devd-fmk, a caspase 3 inhibitor, to block the alpha6beta4-associated reduction in akt/pkb levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of akt/pkb in vitro |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CASP3 | form complex 
binding
|
Caspase 3 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256387 |
|
|
|
|
| pmid |
sentence |
| 15115390 |
Caspases are expressed as inactive proenzymes of 30−50 kDa that include an amino-terminal domain of variable length and sequence that is followed by two domains of conserved sequences: a large subunit (approximately 20 kDa, designated p17 in caspase-3) and a small carboxy-terminal subunit (approximately 10 kDa, designated p12 in caspase-3). Activation is accomplished by proteolytic cleavage between these domains and subsequent assembly of heterotetramers that contain two copies each of the large and small subunits but lack the amino-terminal domains. |
|
| Publications: |
1 |
| + |
Caspase 3 complex | down-regulates quantity by destabilization
cleavage
|
RAD51 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271708 |
|
|
Homo sapiens |
32D Cell |
| pmid |
sentence |
| 11684015 |
The RAD51 protein has been shown to be a substrate for caspase-3|he activated caspase-3 fragments (19 kDa and 17 kDa) and caspase-3 cleaved RAD51 fragment (∼23 kDa) was detected by Western analysis (Figure 3E). Activation of caspase-3 and the signature proteolytic degradation product of RAD51 only occurred in parental 32Dcl3 cells after treatment with cisplatin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
KDM4C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29207681 |
JMJD2C as a novel substrate for caspase-3 (cysteine-aspartic acid protease-3), and cleavage of JMJD2C by caspase-3 led to inactivation of JMJD2C demethylase activity and elevation of H3K9 methylation levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates 
|
Chromatine_condensation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10200555 |
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
STX5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14970262 |
Giantin and syntaxin 5 are cleaved by caspase-3. Given that both giantin and syntaxin 5 are cleaved at an early stage during apoptosis, we anticipated that, at the very least, the delivery of ER-derived transport intermediates to the Golgi would be impaired in apoptotic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
DNA_fragmentation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10200555 |
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256475 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BCR-ABL | down-regulates activity 
|
Caspase 3 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271705 |
|
|
Homo sapiens |
32D Cell |
| pmid |
sentence |
| 11684015 |
BCR/ABL Tyrosine Kinase Enhances Expression of RAD51 by Stimulation of STAT5-Mediated Transactivation and Inhibition of Caspase-3-Dependent Degradation| |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates quantity by stabilization
cleavage
|
NFKBIA |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256456 |
|
|
in vitro |
|
| pmid |
sentence |
| 9367996 |
The cell-death protease cpp32 (caspase-3) in vitro specifically cleaved chicken and human ikappab-alpha at a conserved asp-ser sequence.Therefore, cleavage of I_B-_ by a CPP32-like protease could create what is sometimes called a super-repressor form of I_B-_ (20). That is, cleavage by CPP32 would block the ability of I_B-_ to undergo signal-induced degradation by removing the sites of signal-induced ubiquitination and by likely disrupting the ability of I_B-_ to become phosphorylated at critical Ser residues. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Caspase 3 complex | down-regulates
cleavage
|
PSIP1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256469 |
|
|
Homo sapiens |
Prostate Gland Cancer Cell |
| pmid |
sentence |
| 18708362 |
Ledgf/ p75 has a cooh-terminally truncated splice variant, p52 / during apoptosis, caspase-3 cleaved p52 to generate a p38 fragment that lacked the nh2-terminal pwwp domain and failed to transactivate the hsp27 promoter in reporter assays. However, p38 retained chromatin association properties and repressed the transactivation potential of ledgf/p75 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
cleavage
|
CASP6 |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256467 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9922454 |
Caspase-3 is required for the activation of caspases 6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
BAD |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256455 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15231831 |
Casp3 cleaves bad at asp-61. In addition, caspases convert bad(l) into a pro-death fragment that resembles the short splice variant. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
cleavage
|
ACIN1 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256449 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490026 |
Induces apoptotic chromatin condensation after activation by casp3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Caspase-3 is responsible for apoptosis execution |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Caspase-3 is responsible for apoptosis execution |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates
cleavage
|
SPTAN1 |
0.662 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256450 |
|
|
Homo sapiens |
Breast Cancer Cell, HeLa Cell |
| pmid |
sentence |
| 9624143 |
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
AKT1 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256447 |
|
|
in vitro |
|
| pmid |
sentence |
| 10579725 |
P53 can inhibit the survival function of integrins by inducing the caspase-dependent cleavage and inactivation of the serine/threonine kinase akt/pkb;the involvement of caspase 3 in akt/pkb regulation was indicated by the ability of z-devd-fmk, a caspase 3 inhibitor, to block the alpha6beta4-associated reduction in akt/pkb levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of akt/pkb in vitro |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Caspase 3 complex | down-regulates
cleavage
|
GSN |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256461 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 9323209 |
Caspase-3 mediates cleavage of gelsolin, generating a fragment that severs actin filaments in an unregulated fashion. The cleavage of gelsolin causes cells to round up, detach and undergo nuclear fragmentation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates
|
Protein_degradation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256476 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Caspase 3 complex | up-regulates
|
Membrane_blebbing |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10200555 |
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Caspase 3 complex | up-regulates
cleavage
|
ROCK1 |
0.724 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11283607 |
Rock i is cleaved by casp3 at a conserved detd1113/g sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | down-regulates activity
cleavage
|
PARP1 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256465 |
|
|
Mus musculus |
L-929 Cell |
| pmid |
sentence |
| 11907276 |
Caspase-3 cleaves parp-1. During cd95-mediated apoptosis proteolytic inactivation of parp-1 by caspases prevents atp depletion and thereby ensures the execution of the apoptotic process |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Caspase 3 complex | up-regulates
cleavage
|
DFFB |
0.672 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256463 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9108473 |
Casp3_ cleaves the 45 kda subunit at two sites to generate an active factor that produces_ dna_ fragmentation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 3 complex | up-regulates activity
cleavage
|
DFFA |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256464 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9108473 |
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation in coincubated nuclei after it is activated by caspase-3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Caspase 3 complex
CPX-970