Relation Results

Summary

Name Caspase 3 complex
Primary ID SIGNOR-C221
Links CPX-970
Type complex
Formed by CASP3
Relations 41

Viewer

Type: Score: Layout: SPV 
0.4750.3220.2540.3670.4480.6140.6360.6370.4860.4680.6150.5340.6260.70.6840.20.20.70.20.7330.7750.20.6450.3490.6070.70.70.70.6730.4250.70.70.754Caspase 3 complexBRCA1PTCH1GOLGB1IKBKBGAS2STK4CASP9GSNIL18RAD51CASP6BADACIN1ApoptosisDFFBKDM4CCASP3Muscle_atrophyBCR-ABLROCK1PARP1STX5AKTPSIP1AKT1Protein_degradationDNA_fragmentationMembrane_blebbingSPTAN1NFKBIAChromatine_condensationCell_deathDFFA

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ Caspase 3 complexdown-regulates quantity by destabilization img/direct_inhibition.png cleavage BRCA1 0.475
Identifier Residue Sequence Organism Cell Line
SIGNOR-256432 Asp1155 ETPDDLLdDGEIKED Homo sapiens
pmid sentence
We demonstrate the cleavage and the consequential downregulation of full-length BRCA1 by caspase-3 during UV-induced apoptosis. Finally, mutation of a caspase-3 specific cleavage site (D/A1154) rendered BRCA1 non-cleavable.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates img/direct_inhibition.png cleavage PTCH1 0.322
Identifier Residue Sequence Organism Cell Line
SIGNOR-256437 Asp1405 CPGYPETdHGLFEDP Homo sapiens
pmid sentence
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage PTCH1 0.322
Identifier Residue Sequence Organism Cell Line
SIGNOR-256438 Asp1405 CPGYPETdHGLFEDP Homo sapiens
pmid sentence
Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage GOLGB1 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-261235 Asp1881 LSQISTKdGELKMLQ Homo sapiens
pmid sentence
Giantin and syntaxin 5 are cleaved by caspase-3. Given that both giantin and syntaxin 5 are cleaved at an early stage during apoptosis, we anticipated that, at the very least, the delivery of ER-derived transport intermediates to the Golgi would be impaired in apoptotic cells.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates img/direct_inhibition.png cleavage IKBKB 0.367
Identifier Residue Sequence Organism Cell Line
SIGNOR-256441 Asp242 VRQKSEVdIVVSEDL Homo sapiens
pmid sentence
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256436 Asp373 PATQCISdGKLNEGH Homo sapiens
pmid sentence
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256435 Asp546 ALQTDIVdLQRSPMG Homo sapiens
pmid sentence
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256434 Asp78 PNVVAARdVPEGMQN Homo sapiens
pmid sentence
Ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis.
Publications: 4 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage GAS2 0.448
Identifier Residue Sequence Organism Cell Line
SIGNOR-256439 Asp278 MLQISRVdGKTSPIQ Homo sapiens
pmid sentence
We now demonstrate that gas2 is a substrate of caspase-3 but not of caspase-6. Proteolytic processing both in vitro and in vivo is dependent on aspartic residue 279.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates activity img/direct-activation.png cleavage STK4 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-256444 Asp326 NSEEDEMdSGTMVRA Chlorocebus aethiops COS Cell
pmid sentence
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256445 Asp349 RVASTMTdGANTMIE Chlorocebus aethiops COS Cell
pmid sentence
In response to apoptotic stimuli, caspase cleavage of mst1 occurs at asp-326 and asp-349, resulting in the separation of its n-terminal kinase domain from the nes-containing c-terminal domain. Thus, caspase cleavage of mst1 serves two purposes: one is activation of mst1 kinase activity and the other is translocation of mst1 into the nucleus.
Publications: 2 Organism: Chlorocebus Aethiops
+ Caspase 3 complexup-regulates activity img/direct-activation.png cleavage CASP9 0.636
Identifier Residue Sequence Organism Cell Line
SIGNOR-256440 Asp330 LRTFDQLdAISSLPT Homo sapiens U-937 Cell
pmid sentence
In turn, casp3 directs feedback cleavage of casp9 at asp-330 to generate p37 and p10 subunits.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256453 Homo sapiens
pmid sentence
Active caspase-3 itself is able to process its upstream , caspase-8 and caspase-9, establishing a self-amplifying loop of caspase activation
Publications: 2 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage GSN 0.637
Identifier Residue Sequence Organism Cell Line
SIGNOR-256433 Asp403 WRDPDQTdGLGLSYL Homo sapiens
pmid sentence
We showed that human gelsolin was cleaved during Fas-mediated apoptosis in vivo and that the caspase-3 cleavage site of human gelsolin was at D352 of DQTD352G. gelsolin seems to have dual functions, i.e., it both prevents and, once cleaved, induces cell death.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates activity img/direct-activation.png cleavage IL18 0.486
Identifier Residue Sequence Organism Cell Line
SIGNOR-256378 Asp71 PLFEDMTdSDCRDNA Homo sapiens THP-1 Cell
pmid sentence
We also found two precursor hIL-18 (prohIL-18)-processing activities in the cytosol of THP.1 cells. These activities were blocked separately by the caspase inhibitors Ac-YVAD-CHO and Ac-DEVD-CHO. Further analyses of the partially purified enzymes revealed that one is caspase-1, which cleaves prohIL-18 at the Asp36-Tyr37 site to generate the mature hIL-18, and the other is caspase-3, which cleaves both precursor and mature hIL-18 at Asp71-Ser72 and Asp76-Asn77 to generate biologically inactive products.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256379 Asp76 MTDSDCRdNAPRTIF Homo sapiens THP-1 Cell
pmid sentence
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells.|Further analyses of the partially purified enzymes revealed that one is caspase-1, which cleaves prohIL-18 at the Asp36-Tyr37 site to generate the mature hIL-18, and the other is caspase-3, which cleaves both precursor and mature hIL-18 at Asp71-Ser72 and Asp76-Asn77 to generate biologically inactive products.
Publications: 2 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates quantity by destabilization img/direct_inhibition.png cleavage RAD51 0.468
Identifier Residue Sequence Organism Cell Line
SIGNOR-271708 Homo sapiens 32D Cell
pmid sentence
The RAD51 protein has been shown to be a substrate for caspase-3|he activated caspase-3 fragments (19 kDa and 17 kDa) and caspase-3 cleaved RAD51 fragment (∼23 kDa) was detected by Western analysis (Figure 3E). Activation of caspase-3 and the signature proteolytic degradation product of RAD51 only occurred in parental 32Dcl3 cells after treatment with cisplatin
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage CASP6 0.615
Identifier Residue Sequence Organism Cell Line
SIGNOR-256467 Homo sapiens
pmid sentence
Caspase-3 is required for the activation of caspases 6
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates activity img/direct-activation.png cleavage BAD 0.534
Identifier Residue Sequence Organism Cell Line
SIGNOR-256455 Homo sapiens Neuron
pmid sentence
Casp3 cleaves bad at asp-61. In addition, caspases convert bad(l) into a pro-death fragment that resembles the short splice variant.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage ACIN1 0.626
Identifier Residue Sequence Organism Cell Line
SIGNOR-256449 Homo sapiens
pmid sentence
Induces apoptotic chromatin condensation after activation by casp3
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/indirect-activation.png Apoptosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256474 Homo sapiens
pmid sentence
Caspase-3 is responsible for apoptosis execution
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage DFFB 0.684
Identifier Residue Sequence Organism Cell Line
SIGNOR-256463 Homo sapiens
pmid sentence
Casp3_ cleaves the 45 kda subunit at two sites to generate an active factor that produces_ dna_ fragmentation
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates img/direct_inhibition.png cleavage GSN 0.637
Identifier Residue Sequence Organism Cell Line
SIGNOR-256461 Homo sapiens Neutrophil
pmid sentence
Caspase-3 mediates cleavage of gelsolin, generating a fragment that severs actin filaments in an unregulated fashion. The cleavage of gelsolin causes cells to round up, detach and undergo nuclear fragmentation.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage KDM4C 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263871 Homo sapiens
pmid sentence
JMJD2C as a novel substrate for caspase-3 (cysteine-aspartic acid protease-3), and cleavage of JMJD2C by caspase-3 led to inactivation of JMJD2C demethylase activity and elevation of H3K9 methylation levels.
Publications: 1 Organism: Homo Sapiens
+ CASP3form complex img/form-complex.png binding Caspase 3 complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-256387
pmid sentence
Caspases are expressed as inactive proenzymes of 30−50 kDa that include an amino-terminal domain of variable length and sequence that is followed by two domains of conserved sequences:  a large subunit (approximately 20 kDa, designated p17 in caspase-3) and a small carboxy-terminal subunit (approximately 10 kDa, designated p12 in caspase-3). Activation is accomplished by proteolytic cleavage between these domains and subsequent assembly of heterotetramers that contain two copies each of the large and small subunits but lack the amino-terminal domains.
Publications: 1
+ Caspase 3 complexup-regulates img/indirect-activation.png Muscle_atrophy 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256475 Mus musculus
pmid sentence
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice
Publications: 1 Organism: Mus Musculus
+ BCR-ABLdown-regulates activity img/indirect_inhibition.png Caspase 3 complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271705 Homo sapiens 32D Cell
pmid sentence
BCR/ABL Tyrosine Kinase Enhances Expression of RAD51 by Stimulation of STAT5-Mediated Transactivation and Inhibition of Caspase-3-Dependent Degradation|
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/direct-activation.png cleavage ROCK1 0.733
Identifier Residue Sequence Organism Cell Line
SIGNOR-256460 Homo sapiens
pmid sentence
Rock i is cleaved by casp3 at a conserved detd1113/g sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage PARP1 0.775
Identifier Residue Sequence Organism Cell Line
SIGNOR-256465 Mus musculus L-929 Cell
pmid sentence
Caspase-3 cleaves parp-1. During cd95-mediated apoptosis proteolytic inactivation of parp-1 by caspases prevents atp depletion and thereby ensures the execution of the apoptotic process
Publications: 1 Organism: Mus Musculus
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage STX5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261236 Homo sapiens
pmid sentence
Giantin and syntaxin 5 are cleaved by caspase-3. Given that both giantin and syntaxin 5 are cleaved at an early stage during apoptosis, we anticipated that, at the very least, the delivery of ER-derived transport intermediates to the Golgi would be impaired in apoptotic cells.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage AKT 0.645
Identifier Residue Sequence Organism Cell Line
SIGNOR-256446 in vitro
pmid sentence
P53 can inhibit the survival function of integrins by inducing the caspase-dependent cleavage and inactivation of the serine/threonine kinase akt/pkb;the involvement of caspase 3 in akt/pkb regulation was indicated by the ability of z-devd-fmk, a caspase 3 inhibitor, to block the alpha6beta4-associated reduction in akt/pkb levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of akt/pkb in vitro
Publications: 1 Organism: In Vitro
+ Caspase 3 complexdown-regulates img/direct_inhibition.png cleavage PSIP1 0.349
Identifier Residue Sequence Organism Cell Line
SIGNOR-256469 Homo sapiens Prostate Gland Cancer Cell
pmid sentence
Ledgf/ p75 has a cooh-terminally truncated splice variant, p52 / during apoptosis, caspase-3 cleaved p52 to generate a p38 fragment that lacked the nh2-terminal pwwp domain and failed to transactivate the hsp27 promoter in reporter assays. However, p38 retained chromatin association properties and repressed the transactivation potential of ledgf/p75
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexdown-regulates activity img/direct_inhibition.png cleavage AKT1 0.607
Identifier Residue Sequence Organism Cell Line
SIGNOR-256447 in vitro
pmid sentence
P53 can inhibit the survival function of integrins by inducing the caspase-dependent cleavage and inactivation of the serine/threonine kinase akt/pkb;the involvement of caspase 3 in akt/pkb regulation was indicated by the ability of z-devd-fmk, a caspase 3 inhibitor, to block the alpha6beta4-associated reduction in akt/pkb levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of akt/pkb in vitro
Publications: 1 Organism: In Vitro
+ Caspase 3 complexup-regulates img/indirect-activation.png Protein_degradation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256476 Mus musculus
pmid sentence
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice.
Publications: 1 Organism: Mus Musculus
+ Caspase 3 complexup-regulates img/indirect-activation.png DNA_fragmentation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256478 Homo sapiens
pmid sentence
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates img/indirect-activation.png Membrane_blebbing 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256481 Homo sapiens
pmid sentence
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ Caspase 3 complexdown-regulates img/direct_inhibition.png cleavage SPTAN1 0.673
Identifier Residue Sequence Organism Cell Line
SIGNOR-256450 Homo sapiens Breast Cancer Cell, HeLa Cell
pmid sentence
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis.
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates quantity by stabilization img/direct-activation.png cleavage NFKBIA 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-256456 in vitro
pmid sentence
The cell-death protease cpp32 (caspase-3) in vitro specifically cleaved chicken and human ikappab-alpha at a conserved asp-ser sequence.Therefore, cleavage of I_B-_ by a CPP32-like protease could create what is sometimes called a super-repressor form of I_B-_ (20). That is, cleavage by CPP32 would block the ability of I_B-_ to undergo signal-induced degradation by removing the sites of signal-induced ubiquitination and by likely disrupting the ability of I_B-_ to become phosphorylated at critical Ser residues.
Publications: 1 Organism: In Vitro
+ Caspase 3 complexup-regulates img/indirect-activation.png Chromatine_condensation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256477 Homo sapiens
pmid sentence
Caspase-3 is required for blebbing, chromatin condensation and dna fragmentation
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ Caspase 3 complexup-regulates img/indirect-activation.png Cell_death 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256548 Homo sapiens
pmid sentence
Caspase-3 is responsible for apoptosis execution
Publications: 1 Organism: Homo Sapiens
+ Caspase 3 complexup-regulates activity img/direct-activation.png cleavage DFFA 0.754
Identifier Residue Sequence Organism Cell Line
SIGNOR-256464 Homo sapiens
pmid sentence
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation in coincubated nuclei after it is activated by caspase-3.
Publications: 1 Organism: Homo Sapiens
a simple tooltip