+ |
HSBP1 | up-regulates quantity
relocalization
|
WASH complex |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261007 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
29844016 |
The Trimeric Coiled-Coil HSBP1 Protein Promotes WASH Complex Assembly at Centrosomes |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
HSBP1 | down-regulates activity
binding
|
HSF1 |
0.686 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261181 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
9649501 |
HSBP1 is nuclear-localized and interacts in vivo with the active trimeric state of HSF1 that appears during heat shock. During attenuation of HSF1 to the inert monomer, HSBP1 associates with Hsp70. HSBP1 negatively affects HSF1 DNA-binding activity, and overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. HSF1 interacts with HSBP1 in vivo and is a nuclear localized protein. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |