| + |
PPM1B | down-regulates activity 
dephosphorylation
|
IKBKB |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248343 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248344 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates
dephosphorylation
|
IKBKB |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181663 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181667 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates quantity by destabilization
phosphorylation
|
PPM1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276494 |
Ser195 |
MIQRVNGsLAVSRAL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23756813 |
Here, we show that protein kinase A (PKA) phosphorylates the PP2Cβ, which was inhibited by PKA-specific inhibitor, H89. Mutation analysis of serine residues in PP2Cβ revealed that Ser-195 in PP2Cβ is phosphorylated by PKA. Importantly, PKA inhibition by H89 abrogated the Forskolin-induced destabilization of PP2Cβ against ubiquitin-dependent proteosomal degradation pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
DYRK1A |
0.238 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277108 |
Ser258 |
NTNFRGVsLNLTRKF |
Homo sapiens |
|
| pmid |
sentence |
| 33380426 |
In conclusion, our study demonstrates that DYRK1A autophosphorylates Ser258, the dephosphorylation target of PPM1B, and PPM1B negatively regulates DYRK1A activity.|We found that PPM1B dephosphorylates DYRK1A at Ser258, contributing to the inhibition of DYRK1A activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B |
dephosphorylation
|
CDK9 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181396 |
Thr186 |
NSQPNRYtNRVVTLW |
Homo sapiens |
|
| pmid |
sentence |
| 18829461 |
Taken together, our data indicate that PPM1A and to some extent PPM1B are important negative regulators of P-TEFb function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277154 |
|
|
in vitro |
|
| pmid |
sentence |
| 11104763 |
In vitro, PP2Cbeta-1 dephosphorylated and inactivated TAK1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
TBK1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276985 |
|
|
in vitro |
|
| pmid |
sentence |
| 22750291 |
PPM1B dephosphorylates TBK1 in vivo and in vitro.|These results demonstrate that PPM1B inhibits TBK1 mediated antiviral signaling by directly dephosphorylating TBK1 at Ser172. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
CDK2 |
0.369 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20538721 |
CDK2 can be dephosphorylated and inactivated by protein phosphatase type 2C beta isoform long (PP2Cbetal), a unique phosphatase that was originally cloned from human liver. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
PAX2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251712 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25631048 |
PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HEK-293 Cell |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
MPRIP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277019 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25751141 |
Ppm1b prevents Rip3 auto-activation in resting cells.|Together, these data demonstrate that Ppm1b dephosphorylates Rip3 and thus negatively regulates TNF induced necroptosis in L929 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B | up-regulates activity 
dephosphorylation
|
PPARG |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277073 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23320500 |
Furthermore we show that PPM1B can directly dephosphorylate PPARgamma, both in intact cells and in vitro.|In addition PPM1B increases PPARγ-mediated transcription via dephosphorylation of Ser(112).|The serine/threonine phosphatase PPM1B (PP2Cbeta) selectively modulates PPARgamma activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPM1B
- 
- 