4.0
Summary
| Name |  GLRX3
|
| Full Name | Glutaredoxin-3 |
| Synonyms | PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2 | PICOT, TXNL2 |
| Primary ID | O76003 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GLRX3 | form complex 
binding
|
BOLA2-GLRX3 iron-sulfur cluster assembly complex | 0.576 |
| Publications: | 1 | |||