| + |
STC2 | up-regulates 
|
STAT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260406 |
|
|
Mus musculus |
COS-7 Cell |
| pmid |
sentence |
| 29207625 |
STC2 activates STAT3 signaling pathway in the hypothalamus and GT1-7 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HIF1A | up-regulates quantity by expression 
transcriptional regulation
|
STC2 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18394600 |
With the ChIP assay, we demonstrated the direct binding of HIF-1alpha to STC2 promoter. These findings support the notion that HIF-1 is a potent stimulator of STC2 expression. Collectively, this is the first report to show that STC2 was aberrantly hypermethylated in human cancer cells. The findings demonstrated that STC2 epigenetic inactivation may interfere with HIF-1 mediated activation of STC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STC2 | form complex 
binding
|
STC2/HMOX1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260387 |
|
|
|
COS-7 Cell |
| pmid |
sentence |
| 22503972 |
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein.|Taken together, our findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. |
|
| Publications: |
1 |
3.0
STC2
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