Relation Results

Summary

Name STAT3
Full Name Signal transducer and activator of transcription 3
Synonyms Acute-phase response factor | APRF
Primary ID P40763
Links - -
Type protein
Relations 141
Pathways Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, FAP: IL15, FLT3-ITD signaling, iCAF signaling in PDAC, IL6 Signaling, LIF in PDAC, Leptin Signaling, Macrophage polarization, Macrophage: IL10, Macrophage: IL6, Macrophage: Polarization and myogenesis, Macrophage: TGF beta transcriptional regulation, Multiple sclerosis, Myoblast: IL6 and hypertrophy, Myofiber: IL6 and atrophy, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, SARS-CoV CYTOKINE STORM, Satellite: IL6, T-Lymphocyte: IL10, T-Lymphocyte: IL6, T-Lymphocyte: TGF beta
Inhibitors S3I-201; 5,15-Diphenyl-21H,23H-porphine
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:106886 ...
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Type: Score: Layout: SPV 
0.6120.7130.3370.5850.560.4090.3810.3330.5780.7420.490.2940.390.3520.4050.20.7960.5270.20.2560.4520.6210.20.2610.5630.2640.8150.6140.440.7850.3790.6080.7290.20.7650.4080.5250.20.5720.6020.6030.270.6310.7510.2840.70.3090.7820.3510.70.6440.70.2610.70.20.6310.8770.70.7830.3720.60.7540.530.7860.4470.4780.7250.7030.3430.4050.4340.4980.5840.6030.5870.2730.70.2790.470.7030.20.6160.7480.5670.6810.6140.4650.20.6180.4730.4620.7880.630.3040.80.5790.3210.5720.3820.3630.3780.20.70.4930.80.20.2MAPK14STAT3MAPK3NEK6PRKCDIRAK1CDK5PTPROPPP1CAMAPK8MTORMAPK9MAP3K1RPS6KA5NLKPRKCESTK3JAK1PTPRDRET/PTC2PTPN4PKMFGFR3PKPTPRGPTPN1PTPRMJAK2PTK6PTPN9SRCPTPRKHCKPTPN2PTPRRPTPN11FGFR4PTPRTHSPA1BIL20RACEBPDSTAT1CD46SMAD3/PIAS3IL6FBXO32ProliferationPLK1VEGFADAB2IPFibrosisIL22RA1M2_polarizationKRT17Epithelial-mesenchymal_transitionSTC2RORCEGFRT_cell_activationCCND1HIC1IL21RLEPRMYOD1IL10ALKTRAF6PIAS3SOCS3CNTFRTRiCHAMPIL20RBFOXP3STAT1/STAT3FOXO1PTPN14PDAC-associated neural remodeling (PANR)MFGE8CASP3DSCAML1BIRC5MYCSMAD2/STAT3/EP300TYK2HGFPTPN6OR5B21TGFB1CD274SP1/STAT3JAK3POMCGAP43S3I-201IL1BHSPA1ASALL4PPARGDUSP22S100A9EML4-ALKCell_growthIL1RN5,15-Diphenyl-21H,23H-porphineDSCAMDUSP3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK14up-regulates img/direct-activation.png phosphorylation STAT3 0.612
Identifier Residue Sequence Organism Cell Line
SIGNOR-154783 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below).
Identifier Residue Sequence Organism Cell Line
SIGNOR-179912 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ MAPK3up-regulates img/direct-activation.png phosphorylation STAT3 0.713
Identifier Residue Sequence Organism Cell Line
SIGNOR-118596 Ser727 NTIDLPMsPRTLDSL Homo sapiens Leukemia Cell
pmid sentence
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1
Identifier Residue Sequence Organism Cell Line
SIGNOR-187779 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1
Identifier Residue Sequence Organism Cell Line
SIGNOR-118600 Tyr705 DPGSAAPyLKTKFIC Homo sapiens Leukemia Cell
pmid sentence
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1
Identifier Residue Sequence Organism Cell Line
SIGNOR-187787 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases these include epidermal growth factor receptor (egfr) kinase,92 src,5 janus-activated kinases (jak), and extracellular signal-regulated kinase (erk)a constitutively active galpha16 mutant, galpha16ql, stimulated stat3-dependent luciferase activity as well as the phosphorylation of stat3 at both tyr705 and ser727. Galpha16ql-induced stat3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (erk1
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ NEK6up-regulates activity img/direct-activation.png phosphorylation STAT3 0.337
Identifier Residue Sequence Organism Cell Line
SIGNOR-273902 Ser727 NTIDLPMsPRTLDSL Homo sapiens HEK-293 Cell
pmid sentence
Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation. These results demonstrate that NEK6 interacts with and phosphorylates STAT3, an event that could play an important role in oncogenesis. For the maximal activation of STAT3 signaling, phosphorylation of both Tyr705 and Ser727 is required. Phosphorylation of Tyr705 induces dimerization, nuclear translocation, and DNA binding of the STAT3 protein, whereas phosphorylation of Ser727 is important for transcriptional activation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273901 Tyr705 DPGSAAPyLKTKFIC Homo sapiens HEK-293 Cell
pmid sentence
Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation. These results demonstrate that NEK6 interacts with and phosphorylates STAT3, an event that could play an important role in oncogenesis. For the maximal activation of STAT3 signaling, phosphorylation of both Tyr705 and Ser727 is required. Phosphorylation of Tyr705 induces dimerization, nuclear translocation, and DNA binding of the STAT3 protein, whereas phosphorylation of Ser727 is important for transcriptional activation.
Publications: 2 Organism: Homo Sapiens
+ PRKCDup-regulates img/direct-activation.png phosphorylation STAT3 0.585
Identifier Residue Sequence Organism Cell Line
SIGNOR-143828 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Abrogation of pkcdelta activity inhibited insulin-induced stat3 phosphorylation, pkcdelta-stat3 association and nuclear translocation.
Publications: 1 Organism: Homo Sapiens
+ IRAK1up-regulates img/direct-activation.png phosphorylation STAT3 0.56
Identifier Residue Sequence Organism Cell Line
SIGNOR-129685 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Irak1 can directly use stat3 as a substrate and cause stat3 serine 727 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ CDK5up-regulates img/direct-activation.png phosphorylation STAT3 0.409
Identifier Residue Sequence Organism Cell Line
SIGNOR-124325 Ser727 NTIDLPMsPRTLDSL Homo sapiens Neuron
pmid sentence
We report here that the cdk5/p35 complex associates with stat3 and phosphorylates stat3 on the ser-727 residue in vitro and in vivo. Ser phosphorylation of stat3 and transcription of stat3 target genes, such as c-fos and junb, in a cdk5-dependent manner.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Myotube, Brain
+ PTPROdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.381
Identifier Residue Sequence Organism Cell Line
SIGNOR-277061 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
In addition, this group found that PTPRO dephosphorylated STAT3 at Y705 and S727 then attenuated STAT3 signalling.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277062 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
In addition, this group found that PTPRO dephosphorylated STAT3 at Y705 and S727 then attenuated STAT3 signalling.
Publications: 2 Organism: Homo Sapiens
+ PPP1CAdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.333
Identifier Residue Sequence Organism Cell Line
SIGNOR-248563 Ser727 NTIDLPMsPRTLDSL Homo sapiens Hep-G2 Cell, U-266 Cell
pmid sentence
Avicins dephosphorylate Stat3 in a variety of human tumor cell lines, leading to a decrease in the transcriptional activity of Stat3.| However, PD98059, an inhibitor of MEK1/2, had no significant effects on avicin-induced dephosphorylation of Stat3 (Ser 727)
Publications: 1 Organism: Homo Sapiens
+ MAPK3up-regulates activity img/direct-activation.png phosphorylation STAT3 0.713
Identifier Residue Sequence Organism Cell Line
SIGNOR-249450 Ser727 NTIDLPMsPRTLDSL Homo sapiens HEK-293 Cell
pmid sentence
The hematopoietic-specific Galpha16 protein has recently been shown to mediate receptor-induced activation of the signal transducer and activator of transcription 3 (STAT3). In the present study, we have delineated the mechanism by which Galpha16 stimulates STAT3 in human embryonic kidney 293 cells. A constitutively active Galpha16 mutant, Galpha16QL, stimulated STAT3-dependent luciferase activity as well as the phosphorylation of STAT3 at both Tyr705 and Ser727. Galpha16QL-induced STAT3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (ERK1),
Publications: 1 Organism: Homo Sapiens
+ MAPK8up-regulates activity img/direct-activation.png phosphorylation STAT3 0.578
Identifier Residue Sequence Organism Cell Line
SIGNOR-235704 Ser727 NTIDLPMsPRTLDSL Homo sapiens BEAS-2B Cell
pmid sentence
Transfection of the cells with sirna specific for jnk1 revealed that jnk silencing reduced serine727 phosphorylation of stat3,
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Macrophage polarization
+ MTORup-regulates img/direct-activation.png phosphorylation STAT3 0.742
Identifier Residue Sequence Organism Cell Line
SIGNOR-161439 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Identifier Residue Sequence Organism Cell Line
SIGNOR-146915 Ser727 NTIDLPMsPRTLDSL Homo sapiens Glioblastoma Cell
pmid sentence
Serine phosphorylation and maximal activation of stat3 during cntf signaling is mediated by the rapamycin target mtor. / a stat3 peptide was efficiently phosphorylated on ser727 in a cntf-dependent manner by mtor
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, FLT3-ITD signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ MAPK9up-regulates img/direct-activation.png phosphorylation STAT3 0.49
Identifier Residue Sequence Organism Cell Line
SIGNOR-179275 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Publications: 1 Organism: Homo Sapiens
+ MAP3K1up-regulates activity img/direct-activation.png phosphorylation STAT3 0.294
Identifier Residue Sequence Organism Cell Line
SIGNOR-236346 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna.
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, Macrophage polarization
+ RPS6KA5up-regulates img/direct-activation.png phosphorylation STAT3 0.39
Identifier Residue Sequence Organism Cell Line
SIGNOR-101251 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
The stat3-mediated transactivation was reduced by blocking the stat3 serine phosphorylation with the mek inhibitor u0126 or by expression of kinase-inactive msk1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-166664 Homo sapiens
pmid sentence
Msk (mitogen- and stress-activated kinase) 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf- b isoform p65 and stat (signal transducer and activator of transcription) 1 and 3
Publications: 2 Organism: Homo Sapiens
+ NLKup-regulates img/direct-activation.png phosphorylation STAT3 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-155828 Ser727 NTIDLPMsPRTLDSL Homo sapiens Breast Cancer Cell
pmid sentence
Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna.
Publications: 1 Organism: Homo Sapiens
+ PRKCEup-regulates img/direct-activation.png phosphorylation STAT3 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-143832 Ser727 NTIDLPMsPRTLDSL Homo sapiens
pmid sentence
Abrogation of pkcdelta activity inhibited insulin-induced stat3 phosphorylation, pkcdelta-stat3 association and nuclear translocation.
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ STK3down-regulates activity img/direct_inhibition.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277599 Thr622 KEGGVTFtWVEKDIS in vitro
pmid sentence
Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6-induced STAT3 dimerization and activation.
Publications: 1 Organism: In Vitro
+ JAK1up-regulates activity img/direct-activation.png phosphorylation, binding STAT3 0.796
Identifier Residue Sequence Organism Cell Line
SIGNOR-187775 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
The activation of stat-3 is regulated by phosphorylation of tyrosine 705 by receptor and nonreceptor protein tyrosine kinases. These include epidermal growth factor receptor (egfr) kinase, src, janus-activated kinases (jak), and extracellular signal-regulated kinase (erk).
Identifier Residue Sequence Organism Cell Line
SIGNOR-249546 Tyr705 DPGSAAPyLKTKFIC Mus musculus
pmid sentence
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253590 Homo sapiens
pmid sentence
IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes.
Identifier Residue Sequence Organism Cell Line
SIGNOR-236369 Homo sapiens
pmid sentence
The binding of lif to the lifr induces its heterodimerization with gp130. The formation of this complex results in the activation of the receptor-associated janus kinases (jaks), in the phosphorylation of receptor docking sites, and finally in the recruitment of src homology-2 (sh2) domain containing proteins such as stat3 (signal transducer and activator of transcription 3).
Publications: 4 Organism: Homo Sapiens, Mus Musculus
Pathways:EBV infection, IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ PTPRDdown-regulates img/direct_inhibition.png dephosphorylation STAT3 0.527
Identifier Residue Sequence Organism Cell Line
SIGNOR-185933 Tyr705 DPGSAAPyLKTKFIC Homo sapiens Lung Cancer Cell, Glioblastoma Cell
pmid sentence
Transfection of wild-type ptprd resulted in the specific dephosphorylation of stat3 at tyrosine 705, a residue that must be phosphorylated for stat3 to be active
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ PTPRDdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.527
Identifier Residue Sequence Organism Cell Line
SIGNOR-248442 Tyr705 DPGSAAPyLKTKFIC Homo sapiens HEK-293 Cell
pmid sentence
Transfection of wild-type PTPRD resulted in the specific dephosphorylation of STAT3 at tyrosine 705, a residue that must be phosphorylated for STAT3 to be active
Publications: 1 Organism: Homo Sapiens
+ RET/PTC2up-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260917 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
In addition, RET/PTC-mediated cellular transformation and proliferation of transformed cells require tyrosine 705 phosphorylation of STAT3 in NIH3T3 cells. We conclude that STAT3 activation by the RET/PTC tyrosine kinase is one of the critical signaling pathways for the regulation of specific genes, such as cyclin D1, vascular endothelial growth factor, and intercellular adhesion molecule 1, and for cellular transformation.
Publications: 1 Organism: Homo Sapiens
+ PTPN4down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.256
Identifier Residue Sequence Organism Cell Line
SIGNOR-277057 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
In terms of molecular mechanisms, we revealed that PTPN4 dephosphorylates pSTAT3 at the Tyr705 residue with a direct interaction, which might provide novel targets for the therapy of CRC.|Loss of PTPN4 Activates STAT3 to Promote the Tumor Growth in Rectal Cancer.
Publications: 1 Organism: Homo Sapiens
+ PKMup-regulates activity img/direct-activation.png phosphorylation STAT3 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-267716 Tyr705 DPGSAAPyLKTKFIC in vitro
pmid sentence
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor
Publications: 1 Organism: In Vitro
Pathways:FLT3-ITD signaling
+ FGFR3up-regulates activity img/direct-activation.png phosphorylation STAT3 0.621
Identifier Residue Sequence Organism Cell Line
SIGNOR-251139 Tyr705 DPGSAAPyLKTKFIC Homo sapiens HEK-293 Cell
pmid sentence
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3.
Publications: 1 Organism: Homo Sapiens
+ PKup-regulates img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268152 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Pkm2 activates transcription of mek5 by phosphorylating stat3 at y705. pkm2 regulates mek5 transcription via activation of stat3
Publications: 1 Organism: Homo Sapiens
+ PTPRGup-regulates activity img/direct-activation.png dephosphorylation STAT3 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-254729 Tyr705 DPGSAAPyLKTKFIC in vitro
pmid sentence
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity.
Publications: 1 Organism: In Vitro
+ PTPN1down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.563
Identifier Residue Sequence Organism Cell Line
SIGNOR-135211 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Mechanism of protein tyrosine phosphatase 1b-mediated inhibition of leptin signalling. Ptp1b plays a critical role in the down-regulation of activated-stat3 by dephosphorylating tyr705, that is the phosphorylation site of activation of stat3.
Publications: 1 Organism: Homo Sapiens
+ PTPN1down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.563
Identifier Residue Sequence Organism Cell Line
SIGNOR-248427 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
PTP1B was able to dephosphorylate activated JAK2 and STAT3 in vitro, whereas either no or a minimal effect was observed with cluster of differentiation 45 (CD45), PTPalpha and leukocyte antigen-related (LAR). By utilisation of a selective PTP1B inhibitor, the leptin-induced STAT3 activation was enhanced in cells. In conclusion, these results suggested that the negative regulatory role of PTP1B on leptin signalling is mediated through a direct and selective dephosphorylation of the two signalling molecules, JAK2 and STAT3.
Publications: 1 Organism: Homo Sapiens
+ PTPRMdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-277016 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Thus PTPRM suppresses STAT3 signaling in DDIAS-knockdown cells, suggesting that DDIAS promotes the IL-6\u2013mediated STAT3 signaling in malignant cancer cells by inhibiting the PTPRM function.|We report that PTPRM is a novel STAT3 tyrosine phosphatase and that it negatively regulates STAT3 activation by dephosphorylating Y705 of STAT3 in the presence of IL-6.
Publications: 1 Organism: Homo Sapiens
+ JAK2up-regulates activity img/direct-activation.png phosphorylation STAT3 0.815
Identifier Residue Sequence Organism Cell Line
SIGNOR-238638 Tyr705 DPGSAAPyLKTKFIC Homo sapiens Hep-G2 Cell
pmid sentence
Inactive cytoplasmic STATs are recruited to the activated receptor by docking of the STAT SH2 domain to selected receptor tyrosine phosphopeptides, where they are in turn phosphorylated on a single tyrosine by Jak kinases. Has been identified tyrosine 705 of Stat3 as the likely site of phosphorylation by Jak kinases during signal transduction.
Identifier Residue Sequence Organism Cell Line
SIGNOR-236463 Tyr705 DPGSAAPyLKTKFIC Homo sapiens Hep-G2 Cell
pmid sentence
Activation of wild type stat3: il-6 treatment causes stat3 recruitment to receptor tyrosine phosphopeptides (gp130) where it is phosphorylated on tyrosine 705 (y) by jak kinase
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, Leptin Signaling, Macrophage polarization
+ PTK6up-regulates activity img/direct-activation.png phosphorylation STAT3 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-278346 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
29 PTK6 promotes activating phosphorylation of STAT3 at tyrosine residue 705.|STAT3 has been shown to promote tumor initiation of different tumor types, including those of the gastrointestinal tract and skin, and PTK6 was previously shown to promote STAT3 activation and tumorigenesis in mouse models of colon and skin cancer.
Publications: 1 Organism: Homo Sapiens
+ PTPN9down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.44
Identifier Residue Sequence Organism Cell Line
SIGNOR-276976 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Results are presented as mean \u00b1 SD from three independent experiments. (B) PTPMeg2 inhibits STAT3-mediated transcriptional activity in a dose dependent manner.|These results indicate that PTPMeg2 inhibits STAT3 activation with certain specificity.|In this study, we demonstrated that PTPMeg2 dephosphorylates STAT3 at the Tyr705 residue by a direct interaction.
Publications: 1 Organism: Homo Sapiens
+ PKMup-regulates img/direct-activation.png phosphorylation STAT3 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-195766 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Pkm2 activates transcription of mek5 by phosphorylating stat3 at y705. pkm2 regulates mek5 transcription via activation of stat3
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ SRCup-regulates activity img/direct-activation.png phosphorylation STAT3 0.785
Identifier Residue Sequence Organism Cell Line
SIGNOR-247341 Tyr705 DPGSAAPyLKTKFIC Homo sapiens HEK-293 Cell
pmid sentence
In the present study, we have delineated the mechanism by which Galpha16 stimulates STAT3 in human embryonic kidney 293 cells. A constitutively active Galpha16 mutant, Galpha16QL, stimulated STAT3-dependent luciferase activity as well as the phosphorylation of STAT3 at both Tyr705 and Ser727.The involvement of tyrosine kinases such as c-Src and Janus kinase 2 and 3 (JAK2 and JAK3) in Galpha16QL-induced activation of STAT3 was illustrated by the combined use of selective inhibitors and dominant negative mutants.
Identifier Residue Sequence Organism Cell Line
SIGNOR-235445 Mus musculus NIH-3T3 Cell
pmid sentence
Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and DNA-binding activity in fibroblasts stably transformed by the Src oncoprotein.We conclude that Stat3 activation by the Src oncoprotein leads to specific gene regulation and that Stat3 is one of the critical signaling pathways involved in Src oncogenesis.
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR Signaling, IL6 Signaling, Rhabdomyosarcoma
+ PTPRKdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.379
Identifier Residue Sequence Organism Cell Line
SIGNOR-277060 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
In this study, we investigated whether receptor-type tyrosine protein phosphatase kappa (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3 specifying motif, negatively regulates STAT3 activation in NKTCL.|Phosphatase substrate-trapping mutant assays demonstrated the binding of PTPRK to STAT3, and phosphatase assays showed that PTPRK directly dephosphorylated phospho-STAT3(Tyr705).
Publications: 1 Organism: Homo Sapiens
+ HCKup-regulates activity img/direct-activation.png phosphorylation STAT3 0.608
Identifier Residue Sequence Organism Cell Line
SIGNOR-251267 Tyr705 DPGSAAPyLKTKFIC in vitro
pmid sentence
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. Direct Phosphorylation of STAT3 on Tyr-705 by Src Family Kinases
Publications: 1 Organism: In Vitro
+ PTPN2down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.729
Identifier Residue Sequence Organism Cell Line
SIGNOR-90818 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
The nuclear isoform of protein-tyrosine phosphatase tc-ptp regulates interleukin-6-mediated signaling pathway through stat3 dephosphorylation.
Publications: 1 Organism: Homo Sapiens
+ PTPN2down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.729
Identifier Residue Sequence Organism Cell Line
SIGNOR-93998 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Upon ligand binding, IL-2R , IL-6R or LeptinR , IFN-_R , IFN-_R and PRLR or growth hormone (GH) receptor associated JAKs become activated. These JAKs mediate phosphorylation of specific tyrosine residues and recruit STATs. Activated STATs are released from the receptor and translocate to the nucleus. PTP1B dephosphorylates JAK2, TYK2 and STAT5 . The 45-kDa form of TC-PTP was shown to dephosphorylate JAK1 and JAK3 as well as STAT1, STAT3 and STAT5.
Publications: 1 Organism: Homo Sapiens
+ PTPRRdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-248719 Tyr705 DPGSAAPyLKTKFIC Homo sapiens Colorectal Cancer Cell Line
pmid sentence
Here, we report identification of signal transducer and activator of transcription 3 (STAT3) as a substrate of PTPRT. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position.
Publications: 1 Organism: Homo Sapiens
+ PTPN11down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.765
Identifier Residue Sequence Organism Cell Line
SIGNOR-272404 Tyr705 DPGSAAPyLKTKFIC Canis lupus familiaris MDCK Cell
pmid sentence
In addition, SHP-2 dephosphorylates tyrosine-phosphorylated Stat1/3/5A (Ohtani et al., 2000; Wu et al., 2002; Chen et al., 2003), and downregulates Stat3-mediated biological actions (Ohtani et al., 2000).|Inhibition of collagen-induced Stat3 tyrosine-705 (Stat3-p-Tyr)
Publications: 1 Organism: Canis Lupus Familiaris
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Leptin Signaling
+ FGFR4up-regulates activity img/direct-activation.png phosphorylation STAT3 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-251142 Tyr705 DPGSAAPyLKTKFIC Homo sapiens
pmid sentence
Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (top). all three FGFR family members examined here are able to lead to Stat activation. Expression of the 'TDII-like' derivatives of FGFR1, FGFR3, and FGFR4, as well as myrR1-WT, led to phosphorylation of both Stat1 and Stat3.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ PTPRTdown-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.525
Identifier Residue Sequence Organism Cell Line
SIGNOR-263981 Tyr705 DPGSAAPyLKTKFIC Homo sapiens HCT-116 Cell, HT-29 Cell
pmid sentence
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277043 Homo sapiens
pmid sentence
Here, we report identification of signal transducer and activator of transcription 3 (STAT3) as a substrate of PTPRT. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position. Accordingly, overexpression of normal PTPRT in colorectal cancer cells reduced the expression of STAT3 target genes.|Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3, and PTPRT specifically dephosphorylated STAT3 at this position.
Publications: 2 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255241 Homo sapiens
pmid sentence
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. Hsp105beta induces Hsp70 expression markedly through the STAT3 pathway in heat-shocked cells. This may represent the mechanism that connects the heat shock protein and STAT families for cell defense against deleterious stress.
Publications: 1 Organism: Homo Sapiens
+ IL20RAup-regulates img/indirect-activation.png STAT3 0.572
Identifier Residue Sequence Organism Cell Line
SIGNOR-86269 Homo sapiens T-lymphocyte, Monocyte
pmid sentence
Il-20 induces cheratin proliferation and stat-3 signal transduction pathway
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPD 0.602
Identifier Residue Sequence Organism Cell Line
SIGNOR-255334 Mus musculus
pmid sentence
P-Stat3 stimulates C/EBPδ expression and activity, which increases myostatin and MAFbx/Atrogin-1 and MuRF-1. Both pathways result in protein losses in muscle.
Identifier Residue Sequence Organism Cell Line
SIGNOR-255333 Mus musculus
pmid sentence
To assess whether Stat3 affects C/EBPδ expression, we co-transfected C2C12 myoblasts with a plasmid expressing a C/EBPδpromoter-driven luciferase plus a lentivirus expressing the constitutively active Stat3C-GFP. Overexpression of Stat3C increased C/EBPδpromoter activity compared to that in lentivirus expressing GFP control
Publications: 2 Organism: Mus Musculus
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAT1 0.603
Identifier Residue Sequence Organism Cell Line
SIGNOR-263650 Homo sapiens Breast Cancer Cell Line
pmid sentence
In summary, we report in this study that STAT1 expression is upregulated by nuclear EGFR, EGFRvIII and HER2, and that STAT3 synergizes with the three receptors to further enhance STAT1 expression. These novel findings establish a novel link between the mitogenic ErbB signaling pathway and the inflammatory pathway mediated by STAT1. The oncogenic transcription factor STAT3 binds to the STAT1 promoter and synergizes with nuclear EGFR to significantly enhance STAT1 gene expression.
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, SARS-CoV CYTOKINE STORM
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD46 0.27
Identifier Residue Sequence Organism Cell Line
SIGNOR-255238 Homo sapiens
pmid sentence
The CD46 promoter contains two binding sites for activated STAT3 and mutations introduced into the major site abolished STAT3 binding. Chromatin immunoprecipitation confirms binding of STAT3 to the CD46 promoter. CD46 promoter activity is induced by activation of STAT3 and blocked by a dominant-negative form of STAT3 in luciferase reporter assays.
Publications: 1 Organism: Homo Sapiens
+ SMAD3/PIAS3down-regulates img/direct_inhibition.png STAT3 0.631
Identifier Residue Sequence Organism Cell Line
SIGNOR-255036 Homo sapiens
pmid sentence
In summary, the TGF-b/IL-6/TCR-pERK-Smad2L (Ser255) axis is the positive regulator, whereas unphosphorylated Smad3C-PIAS3 complex is the negative regulator of STAT3-induced transcriptional processes for TH17 differentiation
Publications: 1 Organism: Homo Sapiens
+ IL6up-regulates activity img/indirect-activation.png STAT3 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-255415 Rattus norvegicus
pmid sentence
IL-6 induced dose-dependent increase in satellite cell proliferation by activating the JAK2/STAT3/cyclin D1 pathway.Treatment with 1 ng/ml IL-6 for 3 h significantly increased p-STAT3+/MyoD+ cell numbers by 44% compared to control media only .
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FBXO32 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-255331 Mus musculus
pmid sentence
Thus we infected C2C12 myofibers with a recombinant adenovirus expressing a mutant, constitutively activated STAT3 (cSTAT3) known to possess increased DNA binding/transcriptional activity. Consistent with wasting, atrogin-1 expression was also markedly increased (Fig. 3A). Thus STAT3 activation is by itself sufficient to induce muscle fiber wasting in cell culture.
Publications: 1 Organism: Mus Musculus
+ STAT3up-regulates img/indirect-activation.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256256 Homo sapiens Mesenchymal Stem Cell
pmid sentence
In summary, our results indicate IL-15 can stimulate the proliferation of FAPs through Jak-STAT pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-245048 Homo sapiens Satellite Cell
pmid sentence
STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Identifier Residue Sequence Organism Cell Line
SIGNOR-255632 Homo sapiens Satellite Cell
pmid sentence
Altogether, these data demonstrate that IL-6 loss results in deficient STAT3 signaling in activated satellite cells, leading to their reduced proliferation and myogenic progression, and highlight the major role played by the IL-6/STAT3 axis in controlling these processes during compensatory hypertrophy.
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, EBV infection, FLT3-ITD signaling, IL6 Signaling, Leptin Signaling, Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation PLK1 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-271690
pmid sentence
Stat3 directly activated transcription of PLK1 in esophageal cancer cells and mouse embryonic fibroblast cell NIH3T3.
Publications: 1
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation VEGFA 0.782
Identifier Residue Sequence Organism Cell Line
SIGNOR-259456 Homo sapiens
pmid sentence
Stat3 directly regulated the promoter of the VEGF gene. Blockade of activated Stat3 by ectopic expression of dominant-negative Stat3 significantly inhibited VEGF expression, and the growth and metastasis of human pancreatic cancer cells. 
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ DAB2IPdown-regulates activity img/direct_inhibition.png binding STAT3 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-254761 Homo sapiens Prostate Cancer Cell Line
pmid sentence
DAB2IP could interact with the signal transducer and activator of transcription 3 (STAT3) via its unique PR domain and suppress STAT3 phosphorylation and transactivation, leading to the inhibition of survivin expression in PCa cells.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates img/indirect-activation.png Fibrosis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256257 Homo sapiens
pmid sentence
Taken together, our data show IL-15 can enhance the collagen deposition in vivo after muscle damage and this process can be prevented by blocking Jak-STAT pathway.
Publications: 1 Organism: Homo Sapiens
+ IL22RA1up-regulates img/indirect-activation.png STAT3 0.644
Identifier Residue Sequence Organism Cell Line
SIGNOR-90162 Homo sapiens
pmid sentence
Il-22 also induced serine phosphorylation of stat3 on ser(727).
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates img/indirect-activation.png M2_polarization 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-249547 Homo sapiens
pmid sentence
The data presented this far show that the JAK-STAT signaling pathway and specifically Stat3 and Jak1 are required for induction of IL-10-dependent anti-inflammatory and developmental responses in macrophages.
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-255234 Homo sapiens Keratinocyte
pmid sentence
IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates img/indirect-activation.png Epithelial-mesenchymal_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277690 Homo sapiens
pmid sentence
Collectively, the activation of IL-6/STAT3 pathway contributed to the PSCs-induced EMT i
Publications: 1 Organism: Homo Sapiens
Tissue: Fibroblast
+ STC2up-regulates img/indirect-activation.png STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260406 Mus musculus COS-7 Cell
pmid sentence
STC2 activates STAT3 signaling pathway in the hypothalamus and GT1-7 cells
Publications: 1 Organism: Mus Musculus
+ STAT3up-regulates img/indirect-activation.png RORC 0.631
Identifier Residue Sequence Organism Cell Line
SIGNOR-254303 Homo sapiens
pmid sentence
The inflammatory cytokines IL-6, IL-21 and IL-23 share signaling pathways by activating both STAT1 and STAT3, while IL-1beta is thought to activate the kinases IRAK1 and IRAK2 through recruitment of the adaptor MyD88. Thus, STAT3 is likely to be a common denominator in the induction of RORgammaT and IL-17 expression
Publications: 1 Organism: Homo Sapiens
+ EGFRup-regulates activity img/direct-activation.png phosphorylation STAT3 0.877
Identifier Residue Sequence Organism Cell Line
SIGNOR-235692 Homo sapiens Breast Cancer Cell
pmid sentence
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-121965 Homo sapiens
pmid sentence
The transcription factors stat1, stat3, and stat5 are directly phosphorylated by erbb-1, subsequent to which they dimerize through phosphotyrosine-sh2 domain interactions and translocate to the nucleus to activate gene trascription critical for proliferation.
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ STAT3up-regulates img/indirect-activation.png T_cell_activation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263821 Homo sapiens
pmid sentence
IL-1β, an inflammatory cytokine primarily expressed in activated macrophages, monocytes, and microglia, significantly contributes to MS development. IL-1β promotes differentiation of T cells into Th17 cells via the STAT3 pathway and thereby promotes and aggravates the inflammatory environment in the CNS
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.783
Identifier Residue Sequence Organism Cell Line
SIGNOR-255411 Mus musculus
pmid sentence
We identified cyclin D1 as a STAT3 target gene product downregulated in satellite cells from IL-6-deficient muscle in vitro and in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-253049 Homo sapiens
pmid sentence
Mutagenesis of STAT3 binding sites within the cyclin D1 promoter and chromatin immunoprecipitation studies showed an association between STAT3 and the transcriptional regulation of the human cyclin D1 gene.
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia
+ HIC1down-regulates quantity by repression img/direct_inhibition.png binding STAT3 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-254246 Homo sapiens MDA-MB-231 Cell
pmid sentence
HIC1 interacts with the DNA binding domain of STAT3 and suppresses the binding of STAT3 to its target gene promoters. HIC1 C-terminal domain binds to STAT3. HIC1 mutant defective in STAT3 interaction reduced its repressive effect on STAT3 DNA binding activity, the reporter activity and gene expression of the VEGF and c-Myc genes, and cell growth in MDA-MB 231 cells.
Publications: 1 Organism: Homo Sapiens
+ IL21Rup-regulates img/indirect-activation.png STAT3 0.6
Identifier Residue Sequence Organism Cell Line
SIGNOR-133379 Homo sapiens Monocyte
pmid sentence
Interleukin 24 (il-24) is a new member of the il-10 family of cytokines and it signals through two heterodimeric receptors: il-20r1/il-20r2 and il-22r1/il-20r2. Upon binding to its receptors, il-24 induces rapid activation of stat-1 and stat-3 transcription factors,
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Skin
+ LEPRup-regulates activity img/direct-activation.png phosphorylation, binding STAT3 0.754
Identifier Residue Sequence Organism Cell Line
SIGNOR-263492 Homo sapiens HT-1080 Cell
pmid sentence
These observations indicate that leptin stimulates tyrosine phosphorylation of STAT3 via LEPRb but independent of JAK2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263495 Homo sapiens HEK-293 Cell
pmid sentence
LRb signaling is initiated by leptin binding to the extracellular domain of the LRb dimer, leading to Jak2 transphosphorylation and activation. Activated Jak2 mediates the tyrosine phosphorylation of Tyr985 and Tyr1138of LRb. These phosphotyrosine residues immediately function as binding sites (double-ended lines) for SHP-2 and STAT3, both of which quickly become tyrosine-phosphorylated by Jak2.
Publications: 2 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOD1 0.53
Identifier Residue Sequence Organism Cell Line
SIGNOR-255416 Mus musculus
pmid sentence
Here we show that IL-6-activated Stat3 signaling regulates satellite cell behavior, promoting myogenic lineage progression through myogenic differentiation 1 (Myod1) regulation. IL-6 stimulation promoted an increase in the mRNA levels of both Stat3 and Myod1. Stat3 mediated this effect, as IL-6–dependent Myod1 upregulation was impaired after infection with the shStat3 lentivirus.
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ STAT3up-regulates img/indirect-activation.png transcriptional regulation IL10 0.786
Identifier Residue Sequence Organism Cell Line
SIGNOR-256234 Homo sapiens
pmid sentence
These data argue that, in TH2 cells, STAT3 is required for T cell IL-10 production, which in turn reinforces its own expression
Identifier Residue Sequence Organism Cell Line
SIGNOR-254515 Homo sapiens
pmid sentence
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype
Publications: 2 Organism: Homo Sapiens
Pathways:Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ ALKup-regulates img/direct-activation.png binding STAT3 0.447
Identifier Residue Sequence Organism Cell Line
SIGNOR-139460 Homo sapiens Lymphoma Cell
pmid sentence
Npm-alk has been shown to activate signal transducer and activator of transcription (stat) 3, a transcriptional regulator of cyclin d3.Proteins that interact with alk tyrosine kinase play important roles in mediating downstream cellular signals. Previously reported proteins in the alk signal pathway were identified including pi3-k, jak2, jak3, stat3, grb2, irs, and plcgamma1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-122085 Homo sapiens Lymphoma Cell
pmid sentence
Npm-alk has been shown to activate signal transducer and activator of transcription (stat) 3, a transcriptional regulator of cyclin d3.Proteins that interact with alk tyrosine kinase play important roles in mediating downstream cellular signals. Previously reported proteins in the alk signal pathway were identified including pi3-k, jak2, jak3, stat3, grb2, irs, and plcgamma1.
Publications: 2 Organism: Homo Sapiens
+ TRAF6down-regulates activity img/direct_inhibition.png ubiquitination STAT3 0.478
Identifier Residue Sequence Organism Cell Line
SIGNOR-278618 Homo sapiens
pmid sentence
TRAF6 Interacts with STAT3 and Mediates the Ubiquitination of STAT3.|TRAF6 Represses the Transcriptional Activity of STAT3.
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ PIAS3down-regulates activity img/direct_inhibition.png binding STAT3 0.725
Identifier Residue Sequence Organism Cell Line
SIGNOR-238648 Homo sapiens
pmid sentence
PIAS3 blocked the DNA- binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ SOCS3down-regulates activity img/indirect_inhibition.png STAT3 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-255330 Homo sapiens
pmid sentence
A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ CNTFRup-regulates img/indirect-activation.png STAT3 0.343
Identifier Residue Sequence Organism Cell Line
SIGNOR-72774 Homo sapiens
pmid sentence
Clc/clf activates stat1 and stat3.
Publications: 1 Organism: Homo Sapiens
+ TRiCup-regulates quantity by stabilization img/direct-activation.png binding STAT3 0.405
Identifier Residue Sequence Organism Cell Line
SIGNOR-272870 Homo sapiens
pmid sentence
Mammalian cells contain an evolutionarily conserved type II chaperonin called chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC). The CCT complex is composed of eight subunits [CCT1-8 (yeast) or CCTα-θ (mammals)] and folds substrates needed for cell invasion and proliferation, such as actin, tubulin, and cell division cycle protein 20 homolog (cdc20), as well as oncoproteins like signal transducer and activator of transcription 3 (STAT3), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Myelocytomatosis (MYC).
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HAMP 0.434
Identifier Residue Sequence Organism Cell Line
SIGNOR-255239 Homo sapiens HuH-7 Cell
pmid sentence
HCV-induced ROS stabilized the expression of two negative hepcidin regulators, HIF1alpha and HIF2alpha, and its expression was decreased by a HDAC inhibitor or an anti-oxidant. HCV-induced ROS also caused hypoacetylation of histones and inhibited binding of two positive regulators, C/EBPalpha and STAT3, to the hepcidin promoter, whereas anti-oxidant treatment of cells recovered C/EBPalpha and STAT3 binding to the hepcidin promoter.
Publications: 1 Organism: Homo Sapiens
+ IL20RBup-regulates img/indirect-activation.png STAT3 0.498
Identifier Residue Sequence Organism Cell Line
SIGNOR-86305 Homo sapiens T-lymphocyte, Monocyte
pmid sentence
Il-20 induces cheratin proliferation and stat-3 signal transduction pathway
Publications: 1 Organism: Homo Sapiens
+ STAT3down-regulates img/indirect_inhibition.png FOXP3 0.584
Identifier Residue Sequence Organism Cell Line
SIGNOR-254304 Homo sapiens
pmid sentence
Our results demonstrate that IL-27 inhibits the acquisition of the Treg phenotype at the level of Foxp3. The inhibitory effect of IL-27 on Treg generation was at least partially signal transducer and activator of transcription 3 (STAT3) dependent as examined by targeted STAT3 protein inhibition using small interfering RNA (siRNA)
Identifier Residue Sequence Organism Cell Line
SIGNOR-254364 Homo sapiens
pmid sentence
Our results demonstrate that IL-27 inhibits the acquisition of the Treg phenotype at the level of Foxp3. The inhibitory effect of IL-27 on Treg generation was at least partially signal transducer and activator of transcription 3 (STAT3) dependent as examined by targeted STAT3 protein inhibition using small interfering RNA (siRNA)
Publications: 2 Organism: Homo Sapiens
+ STAT3form complex img/form-complex.png binding STAT1/STAT3 0.603
Identifier Residue Sequence Organism Cell Line
SIGNOR-235664 Mus musculus Keratinocyte
pmid sentence
Stimulation of EGFR induces Tyr701 phosphorylation of STAT1 and initiates complex formation of STAT1 and STAT3 with JAK1 and JAK2. Thereafter, the STATs translocate to the nucleus within 15 min.
Publications: 1 Organism: Mus Musculus
+ FOXO1down-regulates activity img/direct_inhibition.png binding STAT3 0.587
Identifier Residue Sequence Organism Cell Line
SIGNOR-263496 Homo sapiens HEK-293 Cell
pmid sentence
FoxO1, which is up-regulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to specificity protein 1 (SP1)-pro-opiomelanocortin (POMC) promoter complex, and thereby inhibits STAT3-mediated regulation of POMC transcription.
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Rhabdomyosarcoma
+ PKup-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268149 in vitro
pmid sentence
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor
Identifier Residue Sequence Organism Cell Line
SIGNOR-270312 in vitro
pmid sentence
PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor
Publications: 2 Organism: In Vitro
+ PTPN14down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-277088 Chlorocebus aethiops
pmid sentence
Moreover, dephosphorylation of STAT3 by PTPN14 might occur in the cytoplasm but not in nucleus.|The tyrosine phosphatase PTPN14 inhibits the activation of STAT3 in PEDV infected Vero cells.
Publications: 1 Organism: Chlorocebus Aethiops
+ STAT3up-regulates img/indirect-activation.png PDAC-associated neural remodeling (PANR) 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-278038 Homo sapiens Pancreatic Cancer Cell
pmid sentence
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting factor LIF supports PDAC-associated neural remodeling (PANR).Biological investigations showed that LIF promoted the differentiation of glial nerve sheath Schwann cells and induced their migration by activating JAK/STAT3/AKT signaling.
Publications: 1 Organism: Homo Sapiens
+ PIAS3down-regulates img/direct_inhibition.png sumoylation STAT3 0.725
Identifier Residue Sequence Organism Cell Line
SIGNOR-124723 Homo sapiens
pmid sentence
Stat3 mediated signaling pathways can be inhibited by pias3 (protein inhibitor of activated stat3), which was recently found to regulate protein stability and function by its sumo (small-ubiquitin like modifiers) ligase activity in promoting sumoylation of important nuclear proteins.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ MFGE8up-regulates activity img/indirect-activation.png STAT3 0.279
Identifier Residue Sequence Organism Cell Line
SIGNOR-260654 Homo sapiens
pmid sentence
In an attempt to clarify the direct anti-inflammatory role of MFG-E8, we revealed a distinct signaling pathway where MFG-E8 activates suppressor of cytokine signaling (SOCS) 3 gene expression via STAT3 mediated pathway, which in turn served as a negative regulator for LPS induced TLR4 signaling by targeting NF-κB p65 component, thereby attenuating the down-stream signaling for TNF-α production
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CASP3 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-255335 Mus musculus
pmid sentence
We determined that Stat3 activation increases caspase-3 expression in C2C12 cells.
Publications: 1 Organism: Mus Musculus
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-253583 Homo sapiens
pmid sentence
We also found that the wild type SOCS-3 promoter construct has significantly greater activity in non-small-cell lung cancer cell lines than in normal cells in accordance with STAT3 disregulation in these cells
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ DSCAML1up-regulates activity img/direct-activation.png binding STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264278 Homo sapiens Neuron
pmid sentence
Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domain containing proteins seem to play a central and conserved role in Dscam signaling in the context of dynamic changes of tyrosine‐phosphorylation levels.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC5 0.616
Identifier Residue Sequence Organism Cell Line
SIGNOR-254762 Homo sapiens
pmid sentence
DAB2IP could interact with the signal transducer and activator of transcription 3 (STAT3) via its unique PR domain and suppress STAT3 phosphorylation and transactivation, leading to the inhibition of survivin expression in PCa cells.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png MYC 0.748
Identifier Residue Sequence Organism Cell Line
SIGNOR-255413 Homo sapiens
pmid sentence
Additionally, cMyc, a STAT3 downstream gene, was significantly up-regulated in SCs at T24 versus PRE [...]An increase in the number of cMyc+ SCs indicated that human SCs were induced to proliferate under the control of STAT3 signaling.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Rhabdomyosarcoma
+ STAT3form complex img/form-complex.png binding SMAD2/STAT3/EP300 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-255024 Homo sapiens
pmid sentence
Thus, pSmad2L (Ser255) forms complex with p300 and STAT3 to bind to the proximal promoter of the Rorc and Il17a genes.
Publications: 1 Organism: Homo Sapiens
+ TYK2up-regulates img/direct-activation.png phosphorylation STAT3 0.681
Identifier Residue Sequence Organism Cell Line
SIGNOR-71781 Homo sapiens
pmid sentence
Stat3 activation requires kinase function of tyk2.
Identifier Residue Sequence Organism Cell Line
SIGNOR-256255 Homo sapiens
pmid sentence
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation HGF 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-251742 Mus musculus
pmid sentence
Coexpression of activated c-Src and Stat3 synergistically induced strong HGF promoter activity in SP1 cells
Publications: 1 Organism: Mus Musculus
Pathways:Rhabdomyosarcoma
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-253050 Homo sapiens
pmid sentence
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ PTPN6down-regulates img/direct_inhibition.png dephosphorylation STAT3 0.465
Identifier Residue Sequence Organism Cell Line
SIGNOR-178699 Homo sapiens
pmid sentence
Stat3 may also be a substrate of shp1
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ OR5B21up-regulates activity img/indirect-activation.png STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272503 Homo sapiens
pmid sentence
Since NF-κB activation is an important characteristic of EMT and cancer metastasis, we evaluated the effect of OR5B21 on this pathway as well as two transcription factors known to co-operate with NF-κB as synergistic initiators and master regulators of EMT, the signal transducer and activator of transcription 3 (STAT3) and the CCAAT/enhancer binding protein b (C/EBPβ) | Of importance, OR5B21 knockdown inhibited phosphorylation of STAT3 and reversed the expression of MMP2, MMP9, and Snail, which coincided with a decrease in both C/EBPβ levels and activation of NF-κB, whereas overexpression of OR5B21 had the opposite effect, endorsing the role of C/EBPβ/STAT3 in OR5B21-induced metastasis | Together, these data suggest that OR5B21 promotes breast cancer metastasis to different tissues by activating EMT through the STAT3/NF-κB/C/EBPβ signaling axis, revealing OR5B21 as a potential target for breast cancer therapy
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates img/indirect-activation.png transcriptional regulation TGFB1 0.618
Identifier Residue Sequence Organism Cell Line
SIGNOR-254517 Homo sapiens Macrophage
pmid sentence
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD274 0.473
Identifier Residue Sequence Organism Cell Line
SIGNOR-259188 Homo sapiens
pmid sentence
STAT3 and HIF-1α cooperatively enhance PD-L1 expression in EML4-ALK-translocated pADC cells under hypoxia.The protein-DNA binding assay revealed that pSTAT3 was bound to the PD-L1 promoter region in H23 cells transfected with EML4-ALK.
Publications: 1 Organism: Homo Sapiens
+ STAT3form complex img/form-complex.png binding SP1/STAT3 0.462
Identifier Residue Sequence Organism Cell Line
SIGNOR-187793 Homo sapiens
pmid sentence
Sp1 and stat3 seem to synergistically augment renalase transcription.
Publications: 1 Organism: Homo Sapiens
+ SOCS3down-regulates img/indirect_inhibition.png STAT3 0.703
Identifier Residue Sequence Organism Cell Line
SIGNOR-249567 Homo sapiens Macrophage
pmid sentence
SOCS3 attenuates IL-6-induced STAT3 anti-inflammatory effects, as well as IL-4-induced insulin receptor substrate-2/PI3K-mediated gene expression.
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Leptin Signaling
+ JAK3up-regulates img/direct-activation.png phosphorylation STAT3 0.788
Identifier Residue Sequence Organism Cell Line
SIGNOR-256254 Homo sapiens
pmid sentence
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation POMC 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-263497 Homo sapiens HEK-293 Cell
pmid sentence
We show that phospho-STAT3 activates POMC promoter in response to leptin signaling through a mechanism that requires an SP1-binding site in the POMC promoter.
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ STAT3up-regulates quantity by expression img/direct-activation.png transcriptional regulation GAP43 0.304
Identifier Residue Sequence Organism Cell Line
SIGNOR-266772 Rattus norvegicus Astrocyte
pmid sentence
 In this study, we demonstrated for the first time that growth-associated protein 43 (GAP43), a well known growth cone protein that promotes axonal regeneration, can be induced in rat brain astrocytes by the proinflammatory endotoxin lipopolysaccharide via both nuclear factor-κB and signal transducer and activator of transcription 3-mediated transcriptional activation.
Publications: 1 Organism: Rattus Norvegicus
+ S3I-201down-regulates img/direct_inhibition.png chemical inhibition STAT3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-194847 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ IL1Bup-regulates activity img/indirect-activation.png STAT3 0.579
Identifier Residue Sequence Organism Cell Line
SIGNOR-263820 Homo sapiens Helper T-lymphocyte
pmid sentence
IL-1β, an inflammatory cytokine primarily expressed in activated macrophages, monocytes, and microglia, significantly contributes to MS development. IL-1β promotes differentiation of T cells into Th17 cells via the STAT3 pathway and thereby promotes and aggravates the inflammatory environment in the CNS
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.321
Identifier Residue Sequence Organism Cell Line
SIGNOR-255240 Homo sapiens
pmid sentence
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. Hsp105beta induces Hsp70 expression markedly through the STAT3 pathway in heat-shocked cells. This may represent the mechanism that connects the heat shock protein and STAT families for cell defense against deleterious stress.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SALL4 0.572
Identifier Residue Sequence Organism Cell Line
SIGNOR-255244 Homo sapiens MDA-MB-231 Cell
pmid sentence
We further tested the functional relationship between STAT3 and SALL4 using MDA-MB-231, a breast cell line carrying constitutive SALL4 expression and STAT3 activity. Down-regulation of the STAT3 activity using a dominant-negative construct resulted in a significant decrease in the expression of SALL4.
Publications: 1 Organism: Homo Sapiens
+ PPARGdown-regulates img/indirect_inhibition.png STAT3 0.382
Identifier Residue Sequence Organism Cell Line
SIGNOR-249556 Homo sapiens Macrophage
pmid sentence
Transcriptional repression of inflammatory response genes occurs by negative interference of PPARg with the nuclear factor kB (NF-kB), signal transducer and activator of transcription (STAT), and activating protein 1 (AP-1) signaling pathways
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Macrophage polarization
+ DUSP22down-regulates activity img/indirect_inhibition.png dephosphorylation STAT3 0.363
Identifier Residue Sequence Organism Cell Line
SIGNOR-277149 Homo sapiens
pmid sentence
IL-6 and LIF-induced LMW-DSP2 expression in murine testicular or hepatoma cell lines, while LMW-DSP2 overexpression in 293T cells suppressed IL-6-induced phosphorylation and activation of STAT3.|These results strongly suggest that LMW-DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
Publications: 1 Organism: Homo Sapiens
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation S100A9 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-261931 Mus musculus
pmid sentence
Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer.
Publications: 1 Organism: Mus Musculus
Pathways:FLT3-ITD signaling
+ EML4-ALKup-regulates activity img/direct-activation.png phosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259203 Mus musculus NIH-3T3 Cell
pmid sentence
We also found that phosphorylation of both the mitogen-activated proteinkinase (MAPK) ERK and STAT3 was markedly increased inthe cells expressing either variant of EML4-ALK[.]. Oncogenic EML4-ALK tyrosine kinase activates ERKand STAT3 signaling pathways
Publications: 1 Organism: Mus Musculus
+ STAT3up-regulates img/indirect-activation.png Cell_growth 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-252090 Mus musculus
pmid sentence
Constitutive activation of Stat3 signaling is accompanied by upregulation of cyclin D1, c-Myc, and Bcl-x, changes consistent with subversion of normal cellular growth and survival control mechanisms.
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling, IL6 Signaling
+ STAT3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1RN 0.493
Identifier Residue Sequence Organism Cell Line
SIGNOR-254795 Homo sapiens Neutrophil, Monocyte
pmid sentence
The interleukin 1 receptor antagonist (IL-1ra) is an important negative regulator of the inflammatory response, whose genetic deficiency has been recently shown to cause a severe autoinflammatory syndrome in humans. In this study we characterized the molecular mechanisms whereby interleukin 10 (IL-10) potentiates IL-1ra transcription in LPS-stimulated monocytes and neutrophils. our findings uncover a novel mechanism whereby IL-10-activated STAT3 modulates IL-1ra transcription in LPS-treated phagocytes by making IL-1ra promoter accessible to readily available nuclear NF-kappaB.
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ 5,15-Diphenyl-21H,23H-porphinedown-regulates activity img/direct_inhibition.png chemical inhibition STAT3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-238549 Homo sapiens
pmid sentence
15-DPP is an effective STAT3 inhibitor and blocks IL10-mediated signalling in macrophages leading to altered regulation of CNV
Publications: 1 Organism: Homo Sapiens
+ DSCAMup-regulates activity img/direct-activation.png binding STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264277 Homo sapiens Neuron
pmid sentence
Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domain containing proteins seem to play a central and conserved role in Dscam signaling in the context of dynamic changes of tyrosine‐phosphorylation levels.
Publications: 1 Organism: Homo Sapiens
+ DUSP3down-regulates activity img/direct_inhibition.png dephosphorylation STAT3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277070 Homo sapiens
pmid sentence
DUSP3 interacted with the C-terminal domain of STAT3 and dephosphorylated p-Y705 of STAT3.|In summary, DUSP3 downregulated the transcriptional activity of STAT3 via dephosphorylation at Y705 and also suppressed the migratory activity of cancer cells.
Publications: 1 Organism: Homo Sapiens
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