| Name
|
 ZFAND5
|
| Full Name |
AN1-type zinc finger protein 5 |
| Synonyms |
Zinc finger A20 domain-containing protein 2, Zinc finger protein 216 | ZA20D2, ZNF216 |
| Primary ID |
O76080 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
3.0
ubiquitination