+ |
SRP19 | up-regulates activity
binding
|
SRP72 |
0.941 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261166 |
|
|
in vitro |
|
pmid |
sentence |
30649418 |
Mammalian SRP comprises the highly base-paired SRP RNA (also referred to as 7SL RNA) of ∼300 nt and six proteins (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) (Figure (Figure1A).1A). The hierarchy of protein addition always starts with the scaffolding protein SRP19 (together with SRP9/14 for the entire SRP) followed by SRP68/72 and finally by SRP54. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
SRP72 | up-regulates activity
binding
|
SRP68 |
0.989 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261164 |
|
|
in vitro |
|
pmid |
sentence |
30649417 |
Taken together our data show that binding of the SRP68/72 heterodimer follows an ultrasensitive response dependent on the SRP72 C-terminus. Although the large solenoids of SRP68/72 have not been structurally characterized due to intrinsic flexibility, they serve as important contact sites in ribosome interaction. |
|
Publications: |
1 |
Organism: |
In Vitro |