| + |
PRKCG | down-regulates activity 
phosphorylation
|
STK17B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263178 |
Ser351 |
PEDSSMVsKRFRFDD |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 18084041 |
These results suggest that phosphorylation of Ser350 plays an essential role in regulating translocation of DRAK2 to the nucleus from the cytoplasm, possibly by affecting the activity of the NLS. Ectopic expression of PKC-gamma induced cytoplasmic localization of DRAK2 and PKC-gamma phosphorylated Ser350 flanking the NLS. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKD1 | up-regulates activity 
phosphorylation
|
STK17B |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279753 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21148796 |
Coexpression of DRAK2 and a constitutively active PKD mutant (CA-PKD1; PKD1-S738/742E) were sufficient to greatly enhance DRAK2 autophosphorylation, supporting the hypothesis that PKD catalytic activity promotes DRAK2 function.|We note that PKD was able to phosphorylate DRAK2 outside of its C terminus, suggesting that PKD mediated phosphorylation occurs on a site in the 1-290 fragment of DRAK2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STK17B
- 
- 