+ |
RHOBTB3 | down-regulates quantity by destabilization
binding
|
CCNE1 |
0.416 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272131 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
24145166 |
Here we show that RhoBTB3, a Golgi-associated, Rho-related ATPase, regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. Depletion of RhoBTB3 arrested cells in S phase, triggered Golgi fragmentation, and elevated cyclin E levels. On the Golgi, RhoBTB3 bound cyclin E as part of a Cullin3 (CUL3)-dependent RING-E3 ubiquitin ligase complex comprised of RhoBTB3, CUL3, and RBX1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RHOBTB3 | up-regulates activity
binding
|
Cullin 3-RBX1-Skp1 |
0.39 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272132 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
24145166 |
Here we show that RhoBTB3, a Golgi-associated, Rho-related ATPase, regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. Depletion of RhoBTB3 arrested cells in S phase, triggered Golgi fragmentation, and elevated cyclin E levels. On the Golgi, RhoBTB3 bound cyclin E as part of a Cullin3 (CUL3)-dependent RING-E3 ubiquitin ligase complex comprised of RhoBTB3, CUL3, and RBX1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |