Summary

Name TRIM37
Full Name E3 ubiquitin-protein ligase TRIM37
Synonyms Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37 | KIAA0898, MUL, POB1
Primary ID O94972
Links - -
Type protein
Relations 2
Function E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TRIM37 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png ubiquitination TRIM37 0.2
Publications: 1 Organism: Homo Sapiens