3.0
Summary
| Name |  ARHGEF15View Modifications |
| Full Name | Rho guanine nucleotide exchange factor 15 |
| Synonyms | Ephexin-5, E5, Vsm-RhoGEF | KIAA0915 |
| Primary ID | O94989 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EPHB2 | down-regulates quantity by destabilization 
phosphorylation
|
ARHGEF15 | 0.499 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGEF15 | up-regulates activity 
guanine nucleotide exchange factor
|
CDC42 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ARHGEF15 | up-regulates activity
guanine nucleotide exchange factor
|
RHOA | 0.553 |
| Publications: | 1 | Organism: | Homo Sapiens | |