| + |
SLITRK5 | down-regulates activity 
binding
|
SHH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268437 |
|
|
Mus musculus |
Osteoblast |
| pmid |
sentence |
| 34326333 |
SLITRK5 interacts with SHH and PTCH1. Mechanistically, SLITRK5 binds to hedgehog ligands via its extracellular domain and interacts with PTCH1 via its intracellular domain. SLITRK5 is present in the primary cilium, and loss of SLITRK5 enhances SMO ciliary enrichment upon SHH stimulation. Thus, SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts that may be attractive as a therapeutic target to enhance bone formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SLITRK5 | down-regulates activity
binding
|
PTCH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268438 |
|
|
Mus musculus |
Osteoblast |
| pmid |
sentence |
| 34326333 |
SLITRK5 interacts with SHH and PTCH1. Mechanistically, SLITRK5 binds to hedgehog ligands via its extracellular domain and interacts with PTCH1 via its intracellular domain. SLITRK5 is present in the primary cilium, and loss of SLITRK5 enhances SMO ciliary enrichment upon SHH stimulation. Thus, SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts that may be attractive as a therapeutic target to enhance bone formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
SLITRK5
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