Summary

Name UNC5C
Full Name Netrin receptor UNC5C
Synonyms Protein unc-5 homolog 3, Protein unc-5 homolog C | UNC5H3
Primary ID O95185
Links - -
Type protein
Relations 2
Function Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding UNC5C 0.826
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding DCC 0.657
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System