Summary

Name DCC
Full Name Netrin receptor DCC
Synonyms Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC | IGDCC1
Primary ID P43146
Links - -
Type protein
Relations 20
Pathways Axon guidance
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation DCC 0.553
Publications: 2 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DCC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MYO10 0.677
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png binding DCC 0.566
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
+ up-regulates img/indirect-activation.png Chemoattraction_of_axon 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png binding DCC 0.908
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png CACNA1C 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.516
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png binding PTK2 0.711
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png CACNA1D 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DCC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding DCC 0.592
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png CACNA1A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png binding DCC 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png binding DCC 0.643
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
+ up-regulates quantity img/direct-activation.png relocalization DCC 0.677
Publications: 1 Organism: Mus Musculus
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png binding DCC 0.654
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
+ down-regulates activity img/direct_inhibition.png binding DCC 0.645
Publications: 1 Organism: Homo Sapiens
Tissue: Nervous System
Pathways:Axon guidance