Summary

Name CELF2
Full Name CUGBP Elav-like family member 2
Synonyms CELF-2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, ETR-3, Neuroblastoma apoptosis-related RNA-binding protein, hNAPOR, RNA-binding protein BRUNOL-3 | BRUNOL3, CUGBP2, ETR3, NAPOR
Primary ID O95319
Links - -
Type protein
Relations 2
Function RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CELF2 0.327
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CELF2 0.2
Publications: 1 Organism: Homo Sapiens