Summary

Name SRC
Full Name Proto-oncogene tyrosine-protein kinase Src
Synonyms Proto-oncogene c-Src, pp60c-src, p60-Src | SRC1
Primary ID P12931
Links - -
Type protein
Relations 329
Pathways EGFR, IL6 , Rhabdomyosarcoma, Integrin Signalling
Inhibitors bosutinib; ponatinib; PP2; herbimycin; 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; dasatinib (anhydrous); PD173955; Saracatinib; KX2-391
Function Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SRC 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.31
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ANXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VCL 0.14
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.51
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation FLT4 0.14
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2A 0.28
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ARHGAP35 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNND1 0.22
Publications: 8 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation FHIT 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BCAR1 0.31
Publications: 10 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation IGF1R 0.2
Publications: 5 Organism: In Vitro
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation IGF1R 0.2
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation TNS3 0.22
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPTAN1 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation MUC1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation WASF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCAR1 0.4
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KCNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRIN2A 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DAPP1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CAV1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FBXO5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EZR 0.23
Publications: 3 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.22
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation CLTC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS2 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ARHGDIB 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, IL6 , Integrin Signalling, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation ARHGEF4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS16 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VAV3 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BDKRB2 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DAB1 0.14
Publications: 4 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation KCNA3 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation IKBKB 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAV2 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.45
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, IL6 , Integrin Signalling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation STAP2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPK 0.22
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ABL1 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RACK1 0.37
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HNF4A 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DNM1 0.2
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation ANXA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MPZL1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation GJA1 0.44
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GTF2I 0.14
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation BCAR1 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOU
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation VIL1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.28
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR, Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation PRKCI 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TGFBR2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSP90AB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARAF 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation ARAF 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:EGFR
+ down-regulates img/direct_inhibition.png phosphorylation PPP2CA 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.2
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:EGFR, Integrin Signalling, Rhabdomyosarcoma
+ img/unknown.png phosphorylation SH3GL1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SH3GL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.2
Publications: 3 Organism: Homo Sapiens, Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation HRAS 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Integrin Signalling
+ up-regulates img/direct-activation.png phosphorylation WWOX 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation DGKA 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KCNJ1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.23
Publications: 4 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates img/direct-activation.png phosphorylation CBLC 0.38
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HLA-A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.36
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR, IL6
+ up-regulates img/direct-activation.png phosphorylation CYP19A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDPK1 0.4
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:EGFR, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHRNA7 0.14
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT19 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.8
Publications: 8 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates img/direct-activation.png phosphorylation PTK2B 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.39
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.14
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.22
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation NFKBIA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TXK 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTTN 0.34
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PRKD1 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GLRB 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ up-regulates img/direct-activation.png phosphorylation UGT2B7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ENO1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.34
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation AFAP1 0.31
Publications: 4 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation MYLK 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSN 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KA3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CEACAM1 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAPGEF1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLG4 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.28
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation SRC 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.37
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRC 0.35
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SRC 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, IL6 , Integrin Signalling, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png dephosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png dephosphorylation SRC 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HCN4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN6 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARRB1 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SPRY2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BMX 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MMP14 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EMD 0.14
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates quantity img/direct_inhibition.png phosphorylation EPHA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC42 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUP 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIP5K1C 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH5 0.14
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png phosphorylation RRAS 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDH5 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png phosphorylation PLSCR1 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation STAT5A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.36
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
Pathways:EGFR
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.42
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:EGFR, IL6 , Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation TERT 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CDCP1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DDR2 0.31
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AP2B1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.14
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3 0.38
Publications: 2 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates activity img/direct-activation.png phosphorylation PLCG1 0.3
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PTPRA 0.3
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PROM1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDH2 0.22
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation DAG1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation KIT 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation INPPL1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Brain, Myotube
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASA1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LATS1/2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates activity img/direct-activation.png binding SRC 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png SRC 0.14
Publications: 1
+ up-regulates activity img/indirect-activation.png MMP3 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KRAS 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png phosphorylation TIAM1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage AREG 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png phosphorylation IKK-complex 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SRC 0.14
Publications: 1
+ up-regulates img/direct-activation.png cleavage TGFA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGAL 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SRC 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK7 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAC1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png TGFA 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR
+ up-regulates img/direct-activation.png binding SRC 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ up-regulates img/direct-activation.png binding SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SRC 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PTEN 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition SRC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.14
Publications: 1 Organism: In Vitro