3.0
Summary
| Name |  TDP2View Modifications |
| Full Name | Tyrosyl-DNA phosphodiesterase 2 |
| Synonyms | Tyr-DNA phosphodiesterase 2, hTDP2, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, ETS1-associated protein 2, ETS1-associated protein II, EAPII, TRAF and TNF receptor-associated protein, Tyrosyl-RNA phosphodiesterase, VPg unlinkase | EAP2, TTRAP |
| Primary ID | O95551 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK6 | up-regulates activity 
phosphorylation
|
TDP2 | 0.385 |
| Publications: | 2 | Organism: | In Vitro, Homo Sapiens | |
| + | ACVR1B | up-regulates activity
phosphorylation
|
TDP2 | 0.284 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TDP2 | up-regulates activity
binding
|
TRAF6 | 0.384 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRAF6 | up-regulates activity
ubiquitination
|
TDP2 | |
| Publications: | 1 | Organism: | Homo Sapiens | |