+ |
TBK1 | down-regulates activity
phosphorylation
|
DDAH2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275648 |
Ser245 |
GGGDLPNsQEALQKL |
|
|
pmid |
sentence |
33850055 |
TANK-binding kinase 1 (TBK1), a kinase downstream of MAVS, inhibited DDAH2 by phosphorylating DDAH2 at multiple sites. |The T203D, T211D, S245D, and S253D mutations significantly reduced the inhibitory effect of DDAH2 on RLR signaling, suggesting that phosphorylation of these residues was critical for DDAH2 to inhibit activation o |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275646 |
Ser253 |
QEALQKLsDVTLVPV |
|
|
pmid |
sentence |
33850055 |
TANK-binding kinase 1 (TBK1), a kinase downstream of MAVS, inhibited DDAH2 by phosphorylating DDAH2 at multiple sites. |The T203D, T211D, S245D, and S253D mutations significantly reduced the inhibitory effect of DDAH2 on RLR signaling, suggesting that phosphorylation of these residues was critical for DDAH2 to inhibit activation o |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275645 |
Thr203 |
VRAMAVLtDHPYASL |
|
|
pmid |
sentence |
33850055 |
TANK-binding kinase 1 (TBK1), a kinase downstream of MAVS, inhibited DDAH2 by phosphorylating DDAH2 at multiple sites. |The T203D, T211D, S245D, and S253D mutations significantly reduced the inhibitory effect of DDAH2 on RLR signaling, suggesting that phosphorylation of these residues was critical for DDAH2 to inhibit activation o |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275647 |
Thr211 |
DHPYASLtLPDDAAA |
|
|
pmid |
sentence |
33850055 |
TANK-binding kinase 1 (TBK1), a kinase downstream of MAVS, inhibited DDAH2 by phosphorylating DDAH2 at multiple sites. |The T203D, T211D, S245D, and S253D mutations significantly reduced the inhibitory effect of DDAH2 on RLR signaling, suggesting that phosphorylation of these residues was critical for DDAH2 to inhibit activation o |
|
Publications: |
4 |
+ |
DDAH2 | up-regulates quantity
|
nitric oxide |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275649 |
|
|
|
|
pmid |
sentence |
33850055 |
Upon viral infection, DDAH2 relocated to mitochondria, where it induced the production of nitric oxide (NO) and the activation of dynamin-related protein 1 (Drp1) |
|
Publications: |
1 |