| + |
KMT2E (isoform 8) | up-regulates activity 
binding
|
NCR2 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260042 |
|
|
Homo sapiens |
Leukemia Cell Line |
| pmid |
sentence |
| 23958951 |
We identify natural cytotoxicity receptor NKp44 (NKp44L), a novel isoform of the mixed-lineage leukemia-5 protein, as a cellular ligand for NKp44. Unlike the other MLL family members, NKp44L is excluded from the nucleus, but expressed at the cell-surface level; its subcellular localization is being associated with the presence of a specific C-terminal motif. Strikingly, NKp44L has not been detected on circulating cells isolated from healthy individuals, but it is expressed on a large panel of the tumor and transformed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KMT2E | up-regulates activity
binding
|
NCR2 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260045 |
|
|
Homo sapiens |
Leukemia Cell Line |
| pmid |
sentence |
| 23958951 |
We identify natural cytotoxicity receptor NKp44 (NKp44L), a novel isoform of the mixed-lineage leukemia-5 protein, as a cellular ligand for NKp44. Unlike the other MLL family members, NKp44L is excluded from the nucleus, but expressed at the cell-surface level; its subcellular localization is being associated with the presence of a specific C-terminal motif. Strikingly, NKp44L has not been detected on circulating cells isolated from healthy individuals, but it is expressed on a large panel of the tumor and transformed cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCR2 | up-regulates 
|
Immune_response |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260044 |
|
|
Homo sapiens |
Natural Killer Cell |
| pmid |
sentence |
| 22021614 |
NK cells play an important role in the early immune response to cancer. The NKp44 activating receptor is the only natural cytotoxicity receptor that is expressed exclusively by primate NK cells, yet its cellular ligands remain largely unknown. Proliferating cell nuclear Ag (PCNA) is overexpressed in cancer cells. In this study, we show that the NKp44 receptor recognizes PCNA. Their interaction inhibits NK cell function through NKp44/ITIM. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCNA | down-regulates activity 
binding
|
NCR2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260043 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22021614 |
NK cells play an important role in the early immune response to cancer. The NKp44 activating receptor is the only natural cytotoxicity receptor that is expressed exclusively by primate NK cells, yet its cellular ligands remain largely unknown. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NCR2
- 
- 