3.0
Summary
| Name |  PCNAView Modifications |
| Full Name | Proliferating cell nuclear antigen |
| Synonyms | PCNA, Cyclin |
| Primary ID | P12004 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | UBE2A | up-regulates 
ubiquitination
|
PCNA | 0.492 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | EGFR | up-regulates
phosphorylation
|
PCNA | 0.347 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDKN1A | down-regulates 
binding
|
PCNA | 0.748 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCNA | down-regulates activity
binding
|
NCR2 | 0.31 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TFDP1 | up-regulates quantity by expression 
transcriptional regulation
|
PCNA | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAD18 | up-regulates
ubiquitination
|
PCNA | 0.837 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PCNA | up-regulates activity
binding
|
DNA polymerase delta | 0.759 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | RF-C complex | up-regulates activity
binding
|
PCNA | 0.805 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | PCNA | up-regulates activity
binding
|
DNA polymerase epsilon | 0.553 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SHPRH | up-regulates
ubiquitination
|
PCNA | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | E2F1 | up-regulates quantity by expression
transcriptional regulation
|
PCNA | 0.471 |
| Publications: | 1 | Organism: | Homo Sapiens | |