| + |
JUN | up-regulates quantity by expression
transcriptional regulation
|
AGR2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282570 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 39914384 |
Chromatin immunoprecipitation followed by quantitative PCR analysis revealed that c-JUN binds to the AGR2 promoter, and this binding is enhanced by IGF1 treatment (Fig 3M). c-JUN knockdown reduced basal AGR2 levels and completely inhibited IGF1-induced AGR2 expression (Fig 3K) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGR2 | up-regulates quantity by stabilization
binding
|
IGF1R |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282571 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 39914384 |
Our analyses demonstrate that IGF1 promotes AGR2 expression and secretion through the IGF1R/c-JUN signaling pathway in PDAC cells. AGR2, in turn, interacts with the precursor form of IGF1R in the ER and facilitates its membrane presentation, establishing a feedback loop within PDAC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |