| Name
|
 GAS8
|
| Full Name |
Dynein regulatory complex subunit 4 |
| Synonyms |
Growth arrest-specific protein 11, GAS-11, Growth arrest-specific protein 8, GAS-8 | DRC4, GAS11 |
| Primary ID |
O95995 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). |
4.0
binding