| + |
PRKAA1 | up-regulates activity 
phosphorylation
|
GSR |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273734 |
Thr507 |
TKADFDNtVAIHPTS |
Homo sapiens |
RKO Cell |
| pmid |
sentence |
| 31530934 |
Mechanistically, AMPKα1 regulate the glutathione reductase (GSR) phosphorylation possibly through residue Thr507 which enhances its activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates quantity by expression
transcriptional regulation
|
GSR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279871 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification.Importantly, GCLC, GCLM, GSS, and GSR are transcriptional targets of NFE2L2. Their upregulation is implicated in conferring resistance to ferroptosis across various contexts, including chemotherapy and radiation therapy |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification.Importantly, GCLC, GCLM, GSS, and GSR are transcriptional targets of NFE2L2. Their upregulation is implicated in conferring resistance to ferroptosis across various contexts, including chemotherapy and radiation therapy |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
4.0
GSR
- 
- 