3.0
Summary
| Name |  KNG1View Modifications |
| Full Name | Kininogen-1 |
| Synonyms | Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, Williams-Fitzgerald-Flaujeac factor | BDK, KNG |
| Primary ID | P01042 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KLKB1 | up-regulates activity 
cleavage
|
KNG1 | 0.773 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||
| + | KNG1 | up-regulates activity
binding
|
GPIb-IX-V complex | 0.423 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KNG1 | up-regulates activity
binding
|
BDKRB2 | 0.853 |
| Publications: | 1 | Organism: | Homo Sapiens | |