| + |
VWF | up-regulates activity 
binding
|
GPIb-IX-V complex |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261853 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Many studies have contributed to shed light on the importance of von Willebrand factor (VWF) interaction with its platelet receptors, glycoprotein (GP) Ib-IX-V and αIIbβ3 integrin, in promoting primary platelet adhesion and aggregation following vessel injury |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SELP | up-regulates activity
binding
|
GPIb-IX-V complex |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261860 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F12 | up-regulates activity
binding
|
GPIb-IX-V complex |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261856 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F11 | up-regulates activity
binding
|
GPIb-IX-V complex |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261857 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GP1BB | form complex 
binding
|
GPIb-IX-V complex |
0.672 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261850 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 16293600 |
The GPIb-V-IX receptor consists of 4 transmembrane subunits: GPIbα, disulfide-linked to GPIbβ, and the noncovalently associated GPIX and GPV components, in ratios of 2:2:2:1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GP5 | form complex
binding
|
GPIb-IX-V complex |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261849 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 16293600 |
The GPIb-V-IX receptor consists of 4 transmembrane subunits: GPIbα, disulfide-linked to GPIbβ, and the noncovalently associated GPIX and GPV components, in ratios of 2:2:2:1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GP1BA | form complex
binding
|
GPIb-IX-V complex |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261847 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 16293600 |
The GPIb-V-IX receptor consists of 4 transmembrane subunits: GPIbα, disulfide-linked to GPIbβ, and the noncovalently associated GPIX and GPV components, in ratios of 2:2:2:1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KNG1 | up-regulates activity
binding
|
GPIb-IX-V complex |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261858 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPIb-IX-V complex | up-regulates activity
relocalization
|
FLNA |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261846 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293600 |
The cytoplasmic domain of GPIbα of the GPIb-IX-V complex binds to actin filaments through FLNa|This immediately means that clustering of the GPIb-IX-V complex and anchoring of FLNa to actin filaments by activation could also increase avidity, which could withstand high shear stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GP9 | form complex
binding
|
GPIb-IX-V complex |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261848 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293600 |
The GPIb-V-IX receptor consists of 4 transmembrane subunits: GPIbalpha, disulfide-linked to GPIbbeta, and the noncovalently associated GPIX and GPV components, in ratios of 2:2:2:1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F2 | up-regulates activity
binding
|
GPIb-IX-V complex |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261859 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 25297919 |
Besides VWF as a main ligand, GPIbα also binds multiple ligands such as thrombospondin, Factor XII, Factor XI, thrombin, High Molecular Weight kininogen, P-selectin and Mac-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPIb-IX-V complex | up-regulates 
|
Platelet_aggregation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32644488 |
Therefore, VWF cannot bind to the GpIb receptors on platelets via the A1 domain to induce platelet aggregation and further hemostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GPIb-IX-V complex
CPX-114