| + |
NPY | up-regulates 
binding
|
NPY2R |
0.832 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9549761 |
Analogs of npy and pyy have been synthesized that contain a proline residue in position 34 of the molecule, i.e., [leu31, pro34]npy (fuhlendorff et al., 1990) or [pro34]pyy (grandt et al., 1994b), and are much more potent at y1 than y2receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NPY | up-regulates
binding
|
NPY1R |
0.853 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9549761 |
Analogs of npy and pyy have been synthesized that contain a proline residue in position 34 of the molecule, i.e., [leu31, pro34]npy (fuhlendorff et al., 1990) or [pro34]pyy (grandt et al., 1994b), and are much more potent at y1 than y2receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NPY | down-regulates 
|
Food intake |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263505 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 10195157 |
Neuropeptide Y (NPY) stimulates food intake and promotes weight gain, whereas melanocortins have the opposite effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
NPY | up-regulates
binding
|
NPY4R |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7592911 |
Human y4 bound human pp family members in i-pyy membrane binding assays with a distinctive rank order (table 1): pp > pyy > npy > npy free acid. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
LEPR | down-regulates quantity
|
NPY |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253075 |
|
|
|
|
| pmid |
sentence |
| 27154742 |
Leptin binding inhibits the neuropeptide Y/agouti-related protein (NPY/AgRP) production and stimulates pro-opiomelanocortin (POMC) production |
|
| Publications: |
1 |
| Pathways: | Leptin Signaling |
| + |
NPY | up-regulates
binding
|
NPY5R |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11825645 |
Npy expression significantly increases whereas the gene expression of its receptors npy1r, npy2r, and npy5r initially decreases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO1 | up-regulates quantity by expression 
transcriptional regulation
|
NPY |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263502 |
|
|
Homo sapiens |
Hypothalamus |
| pmid |
sentence |
| 28270795 |
Foxo1 (when activated) stimulates the transcription of AgRP and NPY, but suppresses the transcription of POMC; thereby antagonizing the transcriptional action of STAT3 in these hypothalamic subpopulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
3.0
NPY
- 
- 