4.0
Summary
| Name |  COL3A1View Modifications |
| Full Name | Collagen alpha-1 |
| Synonyms | CO3A1_HUMAN | |
| Primary ID | P02461 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | ECM: ECM synthesis |
| Function | Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MMP1 | down-regulates quantity by destabilization 
cleavage
|
COL3A1 | 0.351 |
| Publications: | 1 | Organism: | In Vitro | |
| + | COL3A1 | up-regulates 
|
ECM_synthesis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | COLGALT1 | up-regulates activity
glycosylation
|
COL3A1 | 0.406 |
| Publications: | 1 | Organism: | In Vitro | |
| + | COL3A1 | up-regulates activity
binding
|
ADGRG1 | 0.2 |
| Publications: | 1 | |||
| + | COLGALT2 | up-regulates activity
glycosylation
|
COL3A1 | 0.406 |
| Publications: | 1 | Organism: | In Vitro | |