| + |
COL6A6 | up-regulates 
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Collagen | up-regulates 
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269732 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35268340 |
The extracellular matrix is a structure composed of many molecules, including fibrillar (types I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens: types IV, VIII, X), non-collagenous glycoproteins (elastin, laminin, fibronectin, thrombospondin, tenascin, osteopontin, osteonectin, entactin, periostin) embedded in a gel of negatively charged water-retaining glycosaminoglycans (GAGs) such as non-sulfated hyaluronic acid (HA) and sulfated GAGs which are linked to a core protein to form proteoglycans (PGs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A4 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254668 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A3 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254667 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254662 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Collagen is the major structural protein in skeletal muscle ECM;...Several studies suggest that perimysial collagen is predominantly type I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
proline | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255550 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25386178 |
Ornithine, via the enzyme OAT, is also a precursor amino acid for the synthesis of proline, which itself is essential for the synthesis of collagen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL14A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Types XII and XIV collagen are fibril-associated collagens with interrupted triple helices (FACITs) localized primarily to perimysium.23 While they appear to link fibrillar collagen to other ECM components, their precise function is not known |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A6 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL6A3 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254675 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCN2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277683 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33358571 |
As a matricellular protein, connective tissue growth factor (CTGF) functions beyond its classical role in extracellular matrix (ECM) remolding. Increasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL18A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. Types XV and XVIII collagen are classified as multiplexins, which are heparan sulfate proteoglycans (HSPGs). The multiplexins can bind growth factors and also aid in linking the basement membrane to other basement membrane glycoproteins and endomysium |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACTA2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988769 |
It has subsequently been shown that most myofibroblasts express α-SM actin (the actin isoform typically found in vascular SM cells)13,14 and that the expression of α-SM actin and collagen type I in these cells is coordinately regulated by transforming growth factor β1 (TGF-β1)15. All these observations indicate that the myofibroblast has a role in the synthesis of ECM and in force generation, which results in ECM reorganization and wound contraction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
heparan sulfate octasaccharide | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27241222 |
Many observations in animal models deficient for HSPGs and recent observations of human genetic mutations for biosynthesis of HSPGs have identified the importance of HSPGs for normal embryonic development and ECM organization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL15A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254678 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. Types XV and XVIII collagen are classified as multiplexins, which are heparan sulfate proteoglycans (HSPGs). The multiplexins can bind growth factors and also aid in linking the basement membrane to other basement membrane glycoproteins and endomysium |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL6A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A5 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACAN | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266982 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10922468 |
Degradation of aggrecan, the major proteoglycan of the cartilage ECM responsible for the load-bearing and elastic properties of this tissue, is one of the earliest detectable events in arthritic cartilage degeneration. MMPs have been implicated in proteolysis and the subsequent loss of aggrecan from cartilage during arthritis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051604 |
Cartilage oligomeric matrix protein/thrombospondin 5 (COMP/TSP5) is a major component of the extracellular matrix of the musculoskeletal system. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
COL1A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82405 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11007770 |
The present study was designed to further characterize tgfbeta up-regulation of col1a2 and more generally, to increase our understanding of the tgfbeta signaling pathway that controls ecm accumulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL4A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12778132 |
Type IV collagen is the most abundant Type IV collagen is the most abundant constituent of the BM…All of the type IV collagen in mammals is derived from six genetically distinct alpha-chain polypeptides (alpha1-alpha6) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL12A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254671 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Types XII and XIV collagen are fibril-associated collagens with interrupted triple helices (FACITs) localized primarily to perimysium.23 While they appear to link fibrillar collagen to other ECM components, their precise function is not known |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLRP | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Proteoglycans are ubiquitous in connective tissue, and muscle ECM is no exception. A number of PGsare present in muscle ECM, and many belong to the family of small leucine-rich proteoglycans (SLRPs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL3A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Collagen is the major structural protein in skeletal muscle ECM;... type III collagen appears to be more evenly distributed between endomysium and epimysium |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL1A2 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Collagen is the major structural protein in skeletal muscle ECM;...Several studies suggest that perimysial collagen is predominantly type I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL6A1 | up-regulates
|
ECM_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254673 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21949456 |
Muscle basement membrane consists primarily of a type IV collagen network, however types VI, XV, and XVIII are also present. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ECM_synthesis