+ |
PRKN | down-regulates activity
ubiquitination
|
LTF |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278641 |
Lys649 |
NGSDCPDkFCLFQSE |
Homo sapiens |
|
pmid |
sentence |
32786404 |
We propose that Parkin ubiquitylation of LTF at K649 perturbs LTF\u2019s ability to accumulate intracellular iron levels and that depletion of Parkin, or substitution of K649 on LTF, allows LTF to accumulate intracellular iron levels.|Parkin dependent ubiquitylation of LTF occurred most often on lysines (K) 182 and 649. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTF | up-regulates quantity
relocalization
|
iron(3+) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272473 |
|
|
Homo sapiens |
|
pmid |
sentence |
11747454 |
Lactoferrin (Lf), a major iron-binding protein in human milk, has been suggested to have multiple biological roles such as facilitating iron absorption, modulating the immune system, embryonic development, and cell proliferation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CEBPE | up-regulates quantity by expression
transcriptional regulation
|
LTF |
0.375 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-225012 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
15588942 |
C/EBP_ interacts with C/EBP_ through the leucine-zippercontaining domain. C/EBP_ and C/EBP_ synergistically activate transcription of lactoferrin promoter |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LTF | up-regulates activity
binding
|
ITLN1 |
0.366 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272500 |
|
|
Homo sapiens |
|
pmid |
sentence |
23921499 |
Intelectin 1 (IntL) is known as a lectin expressed in intestinal epithelia and also as a receptor for an iron-binding protein, lactoferrin (LF). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CEBPG | up-regulates quantity by expression
transcriptional regulation
|
LTF |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-225015 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
15588942 |
C/EBP_ interacts with C/EBP_ through the leucine-zippercontaining domain. C/EBP_ and C/EBP_ synergistically activate transcription of lactoferrin promoter |
|
Publications: |
1 |
Organism: |
Homo Sapiens |