| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251811 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20617898 |
The endogenous molecule hemoglobin and its derivative heme are often released into tissue compartments where there is infection in the presence of degrading blood. We found that hemoglobin synergizes with multiple TLR agonists to induce high levels of tumor necrosis factor and interleukin-6 from macrophages and that this synergy is independent of TLR4 and MyD88. In contrast, heme synergized with some but not all TLR agonists studied. Furthermore, the synergy of both hemoglobin and heme with lipopolysaccharide was suppressed by hemopexin, a plasma heme-binding protein. |
|
3.0
HPX
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