Summary

Name PDGFA
Full Name Platelet-derived growth factor subunit A
Synonyms PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide | PDGF1
Primary ID P04085
Links - -
Type protein
Relations 4
Pathways FAP: PDGFR alpha, Rhabdomyosarcoma
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PDGFRA 0.764
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung
Pathways:Rhabdomyosarcoma
+ up-regulates img/indirect-activation.png Angiogenesis 0.7
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PDGFA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PDGFA 0.2
Publications: 1 Organism: Homo Sapiens