Relation Results

Summary

Name MAPKAPK3
Full Name MAP kinase-activated protein kinase 3
Synonyms MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP-K3, MAPKAPK-3, MK-3, Chromosome 3p kinase, 3pK
Primary ID Q16644
Links - -
Type protein
Relations 8
Function Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcription ...
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Type: Score: Layout: SPV 
0.6830.4850.3250.2510.711MAPKAPK3HSPB1RCSD1EEF2KCREB5MAPK14

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPKAPK3 img/unknown.png phosphorylation HSPB1 0.683
Identifier Residue Sequence Organism Cell Line
SIGNOR-250159 Ser15 FSLLRGPsWDPFRDW in vitro
pmid sentence
MAPKAP kinase-3 and MAPKAP kinase-2 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates.The three serine residues in HSP27 phosphorylated by MAPKAPK2 were also phosphorylated at the same relative rates by MAPKAP-K3 (Ser-82>>Ser-78 >Ser-15)
Identifier Residue Sequence Organism Cell Line
SIGNOR-250160 Ser78 PAYSRALsRQLSSGV in vitro
pmid sentence
MAPKAP kinase-3 and MAPKAP kinase-2 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates.The three serine residues in HSP27 phosphorylated by MAPKAPK2 were also phosphorylated at the same relative rates by MAPKAP-K3 (Ser-82>>Ser-78 >Ser-15)
Identifier Residue Sequence Organism Cell Line
SIGNOR-250161 Ser82 RALSRQLsSGVSEIR in vitro
pmid sentence
MAPKAP kinase-3 and MAPKAP kinase-2 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates.The three serine residues in HSP27 phosphorylated by MAPKAPK2 were also phosphorylated at the same relative rates by MAPKAP-K3 (Ser-82>>Ser-78 >Ser-15)
Publications: 3 Organism: In Vitro
+ MAPKAPK3down-regulates activity img/direct_inhibition.png phosphorylation RCSD1 0.485
Identifier Residue Sequence Organism Cell Line
SIGNOR-263081 Ser179 RRFRRSQsDCGELGD in vitro
pmid sentence
Human CapZIP was phosphorylated at Ser-179 and Ser-244 by MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) or MAPKAP-K3 in vitro. In the present paper we have identified CapZIP as a protein that is phosphorylated exceptionally rapidly by several SAPKs in vitro (Figure 4), and which is expressed in muscles and immune cells. Both MAPKAP-K2 and MAPKAP-K3 phosphorylated CapZIP at Ser-179 in vitro. An important clue to the function of CapZIP and its phosphorylation came from the finding that it binds to the actin-capping protein CapZ (Figure 7A), and that cellular stresses trigger the dissociation of these two proteins (Figure 7B).Such an effect is presumably lost when CapZIP is phosphorylated and dissociates from CapZ.
Identifier Residue Sequence Organism Cell Line
SIGNOR-263082 Ser244 PPLRRSPsRTEKQEE in vitro
pmid sentence
Human CapZIP was phosphorylated at Ser-179 and Ser-244 by MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) or MAPKAP-K3 in vitro. In the present paper we have identified CapZIP as a protein that is phosphorylated exceptionally rapidly by several SAPKs in vitro (Figure 4), and which is expressed in muscles and immune cells. Both MAPKAP-K2 and MAPKAP-K3 phosphorylated CapZIP at Ser-179 in vitro. An important clue to the function of CapZIP and its phosphorylation came from the finding that it binds to the actin-capping protein CapZ (Figure 7A), and that cellular stresses trigger the dissociation of these two proteins (Figure 7B).Such an effect is presumably lost when CapZIP is phosphorylated and dissociates from CapZ.
Publications: 2 Organism: In Vitro
+ MAPKAPK3 img/unknown.png phosphorylation EEF2K 0.325
Identifier Residue Sequence Organism Cell Line
SIGNOR-249709 Ser377 PPLLRPLsENSGDEN in vitro
pmid sentence
Identification of Ser-377 as the site on eEF2 kinase phosphorylated in vitro by MAPKAP-K2, MAPKAP-K3 and MAPKAP-K5. Maximal phosphorylation of eEF2 kinase by MAPKAP-K2 (Figure 5) or MAPKAP-K5 (results not shown) had no effect on its activity.
Publications: 1 Organism: In Vitro
+ CREB5up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MAPKAPK3 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-253807 Homo sapiens
pmid sentence
Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition),
Publications: 1 Organism: Homo Sapiens
Tissue: Chorda Gubernaculum
+ MAPK14up-regulates activity img/direct-activation.png phosphorylation MAPKAPK3 0.711
Identifier Residue Sequence Organism Cell Line
SIGNOR-235451 Mus musculus NIH-3T3 Cell
pmid sentence
These results, taken together, suggest the importance of the docking interaction in the efficient phosphorylation and activation of 3pk by p38.
Publications: 1 Organism: Mus Musculus
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