| + |
Complement C1 complex | up-regulates activity 
cleavage
|
C2 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263418 |
Arg243 |
KTKESLGrKIQIQRS |
|
|
| pmid |
sentence |
| 31331124 |
C1s subsequently activate serum proteins C4 and C2. C4 is cleaved to fragment C4a, which is an anaphylatoxin, and to fragment C4b, which is deposited on the adjacent surfaces. C2 is cleaved to a fragment C2b, and larger fragment C2a, which binds noncovalently to C4b on the target cell membrane. This forms the C4b2a complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263421 |
Ser20 |
LYPGLADsAPSCPQN |
|
|
| pmid |
sentence |
| 31331124 |
C1s subsequently activate serum proteins C4 and C2. C4 is cleaved to fragment C4a, which is an anaphylatoxin, and to fragment C4b, which is deposited on the adjacent surfaces. C2 is cleaved to a fragment C2b, and larger fragment C2a, which binds noncovalently to C4b on the target cell membrane. This forms the C4b2a complex |
|
| Publications: |
2 |
| Pathways: | Complement Signaling |
| + |
MASP2 | up-regulates activity
cleavage
|
C2 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263416 |
Arg243 |
KTKESLGrKIQIQRS |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263419 |
Ser20 |
LYPGLADsAPSCPQN |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
MASP1 | up-regulates activity
cleavage
|
C2 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263417 |
Arg243 |
KTKESLGrKIQIQRS |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263420 |
Ser20 |
LYPGLADsAPSCPQN |
Homo sapiens |
Plasma Cell |
| pmid |
sentence |
| 11907111 |
The MASPs in the preparations had proteolytic activities against C4, C2, and C3 in the fluid phase |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C2 | form complex 
binding
|
C3 convertase complex |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263399 |
|
|
in vitro |
|
| pmid |
sentence |
| 17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
4.0
C2
- 
- 