| + |
PP1 | down-regulates activity 
dephosphorylation
|
PYGL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267403 |
Ser15 |
QEKRRQIsIRGIVGV |
Homo sapiens |
|
| pmid |
sentence |
| 22225877 |
GP is the first protein whose function was discovered to be regulated by reversible protein phosphorylation, which is controlled by phosphorylase kinase (PhK) and protein phosphatase 1 (PP1). Here we report that lysine acetylation negatively regulates GP activity by both inhibiting enzyme activity directly and promoting dephosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHKG1 | up-regulates activity 
phosphorylation
|
PYGL |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267399 |
Ser15 |
QEKRRQIsIRGIVGV |
Homo sapiens |
Chang Cell |
| pmid |
sentence |
| 22225877 |
It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PHKG2 | up-regulates activity
phosphorylation
|
PYGL |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267401 |
Ser15 |
QEKRRQIsIRGIVGV |
Homo sapiens |
Chang Cell |
| pmid |
sentence |
| 22225877 |
It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OGT | up-regulates activity
glycosylation
|
PYGL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267988 |
Ser430 |
VDRLRRMsLIEEEGS |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 34939084 |
O-GlcNAcylation at Ser-430 promotes PYGL activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PYGL | down-regulates quantity
chemical modification
|
glycogen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3346228 |
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267392 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3346228 |
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RIPK3 | up-regulates
binding
|
PYGL |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19632174 |
Rip3 directly interacts with glycogen phosphorylase (pygl), glutamate ammonia ligase (glul), and glutamate dehydrogenase 1 (glud1). Rip kinase activity is required to enhance the activities of all three enzymes both in vivo and in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PYGL | up-regulates quantity
chemical modification
|
alpha-D-glucose 1-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3346228 |
Mammalian glycogen phosphorylases are found in at least three isozymic forms that can be distinguished by functional and structural properties as well as by the tissues in which they are preferentially expressed […] Each phosphorylase isozyme fulfills different physiological requirements even though all forms of the enzyme catalyze the same reaction, the phosphorolysis of glycogen to yield glucose 1-phosphate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CP-91149 | down-regulates
chemical inhibition
|
PYGL |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PYGL
- 
- 