3.0
Summary
| Name |  HNRNPCView Modifications |
| Full Name | Heterogeneous nuclear ribonucleoproteins C1/C2 |
| Synonyms | hnRNP C1/C2 | HNRPC |
| Primary ID | P07910 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1A1 | down-regulates 
phosphorylation
|
HNRNPC | 0.361 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK2A1 | down-regulates activity
phosphorylation
|
HNRNPC | 0.364 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1A1 | down-regulates activity
phosphorylation
|
HNRNPC | 0.361 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CSNK2A2 |
phosphorylation
|
HNRNPC | 0.331 |
| Publications: | 1 | Organism: | In Vitro | |