Summary

Name HNRNPC
Full Name Heterogeneous nuclear ribonucleoproteins C1/C2
Synonyms hnRNP C1/C2 | HNRPC
Primary ID P07910
Links - -
Type protein
Relations 5
Function Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPC 0.361
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HNRNPC 0.331
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPC 0.361
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HNRNPC 0.364
Publications: 1 Organism: Homo Sapiens