Summary

Name CHRM2
Full Name Muscarinic acetylcholine receptor M2
Synonyms ACM2_HUMAN
Primary ID P08172
Links - -
Type protein
Relations 26
Inhibitors dicyclomine; pirenzepine; oxybutynin; solifenacin; Hexocyclium; aclidinium; amitriptyline; atropine; tiotropium; dothiepin
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNAI3 0.372
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 2 Organism: Homo Sapiens, Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.488
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/indirect-activation.png GNAO1 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAO1 0.329
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition CHRM2 0.8
Publications: 1 Organism: Cricetulus Griseus