Summary

Name GNAI1
Full Name Guanine nucleotide-binding protein G
Synonyms Adenylate cyclase-inhibiting G alpha protein
Primary ID P63096
Links - -
Type protein
Relations 153
Pathways Neutrophils: G-protein-coupled receptor, Neurotransmitters release, Oxytocin signaling
Inhibitors GDP
Function Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding Adenylate_cyclase 0.614
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDC42 0.498
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TNFAIP8 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.609
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Microtubule_polimerization 0.7
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.476
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.443
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.429
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.372
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.274
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.406
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png 3',5'-cyclic AMP 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release, Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Tubulin 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding GNAI1 0.492
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.293
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.406
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.609
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png binding GNAI1 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.468
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.424
Publications: 2 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.488
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.558
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.442
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.385
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.271
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PLD2 0.313
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png binding GNAI1 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.427
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.488
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition GNAI1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.352
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.406
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.289
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAC1 0.441
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding GNAI1 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.455
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png binding GNAI1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png GNAI1 0.476
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.429
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.499
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.534
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ADCY1 0.53
Publications: 2 Organism: Homo Sapiens
Pathways:Neurotransmitters release
+ up-regulates activity img/direct-activation.png binding HCK 0.326
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.402
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.271
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.298
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SRC 0.46
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAI1 0.319
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.433
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.427
Publications: 1
+ up-regulates activity img/direct-activation.png binding GNAI1 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation GNAI1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.438
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.419
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.353
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.429
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GNAI1 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.418
Publications: 1 Organism: Homo Sapiens