| + |
SYP | up-regulates 
|
Synaptic_vesicle_recycling |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264111 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 33769286 |
This study reveals that Syp has a single physiological role in SV recycling, the accurate trafficking, and retrieval of SybII. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
SYP | up-regulates quantity 
binding
|
VAMP2 |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17331077 |
Synaptophysin I interacts with VAMP2 and controls its subcellular distribution. On the SV membrane, VAMP2 is engaged in a complex with synaptophysin I, which is mutually exclusive with the formation of fusogenic SNARE complexes. This model implicates synaptophysin I in escorting VAMP2 to the sites where exocytosis must take place exclusively after the arrival of the appropriate stimulus. We show that, at early stages along the secretory pathway, synaptophysin I directs sorting of VAMP2 to vesicles exhibiting limited availability for constitutive exocytosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26903854 |
Recent studies have revealed that sybII and synaptotagmin-1 interact with other SV cargoes to ensure a high fidelity of retrieval. These cargoes are synaptophysin (for sybII) and SV2A (for synaptotagmin-1). SV2A Acts as an iTRAP to Direct Synaptotagmin-1 Retrieval to SVs. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
DNM1 | up-regulates activity
binding
|
SYP |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10823955 |
The GTPase dynamin I is required for synaptic vesicle (SV) endocytosis. Our observation that dynamin binds to the SV protein synaptophysin in a Ca2+-dependent fashion suggested the possibility that a dynamin/synaptophysin complex functions in SV recycling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
PKNOX1 | up-regulates quantity by expression
transcriptional regulation
|
SYP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254923 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20864515 |
Prep1 overexpression in HepG2 liver cells upregulated SYP and SHP1 and inhibited insulin-induced IR and IRS1/2 phosphorylation and was accompanied by reduced glycogen content. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SYP
- 
- 