Summary

Name CYP21A2
Full Name Steroid 21-hydroxylase
Synonyms 21-OHase, Cytochrome P-450c21, Cytochrome P450 21, Cytochrome P450 XXI, Cytochrome P450-C21, Cytochrome P450-C21B | CYP21, CYP21B
Primary ID P08686
Links - -
Type protein
Relations 4
Pathways Sex Hormone Biosynthesis
Function A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids (PubMed:25855791, PubMed:10602386, PubMed:16984992, PubMed:22014889, PubMed:27721825). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25855791).

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Relations

Regulator Mechanism target score ℹ
+ CYP21A2up-regulates quantity img/direct-activation.png chemical modification 11-deoxycorticosterone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Glomerulosa
Pathways:Sex Hormone Biosynthesis
+ CYP21A2up-regulates quantity img/direct-activation.png chemical modification 17alpha-hydroxyprogesterone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Fasciculata
Pathways:Sex Hormone Biosynthesis
+ CYP21A2down-regulates quantity img/direct_inhibition.png chemical modification progesterone 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Glomerulosa
Pathways:Sex Hormone Biosynthesis
+ CYP21A2down-regulates quantity img/direct_inhibition.png chemical modification 11-deoxycortisol 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Fasciculata
Pathways:Sex Hormone Biosynthesis