3.0
Summary
| Name |  DLDView Modifications |
| Full Name | Dihydrolipoyl dehydrogenase, mitochondrial |
| Synonyms | Dihydrolipoamide dehydrogenase, Glycine cleavage system L protein | GCSL, LAD, PHE3 |
| Primary ID | P09622 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RIPK3 | up-regulates activity 
phosphorylation
|
DLD | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | DLD | form complex 
binding
|
Glycine cleavage system | 0.634 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DLD | form complex
binding
|
OGDC | 0.849 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle | |||
| + | DLD | form complex
binding
|
PDH | 0.851 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle | |||