| Name
|
 UCHL1
|
| Full Name |
Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| Synonyms |
UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1 |
| Primary ID |
P09936 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Pathways |
Parkinson |
| Function |
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865). |
3.0
cleavage