3.0
Summary
| Name |  WEE2View Modifications |
| Full Name | Wee1-like protein kinase 2 |
| Synonyms | EC 2.7.10.2, Wee1-like protein kinase 1B, Wee1B kinase | WEE1B |
| Primary ID | P0C1S8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250|UniProtKB:Q66JT0, ECO:0000269|PubMed:29606300}. |
phosphorylation