Summary

Name H2AB1
Full Name Histone H2A-Bbd type 1
Synonyms H2A Barr body-deficient, H2A.B, H2A.Bbd | H2AFB1
Primary ID P0C5Y9
Links - -
Type protein
Relations 1
Function Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).

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Relations

Regulator Mechanism target score ℹ
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AB1 0.2
Publications: 1 Organism: Homo Sapiens