Summary

Name
Full Name Immunoglobulin gamma-1 heavy chain
Synonyms Immunoglobulin gamma-1 heavy chain NIE |
Primary ID P0DOX5
Links - -
Type protein
Relations 2
Function Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Pr3-ANCA
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MPO-ANCA
Publications: 1 Organism: Homo Sapiens