| + |
Pr3-ANCA | up-regulates 
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2161532 |
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
| form complex 
binding
|
Pr3-ANCA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270594 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27464484 |
Although the majority of PR3-ANCAs are of the IgG isotype, the results of one study showed that PR3-ANCAs of the IgA isotype were present in up to 30% of patients with GPA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAMPs | up-regulates quantity
|
Pr3-ANCA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. |using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
PRTN3 | up-regulates activity 
binding
|
Pr3-ANCA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
ANCAs comprise a group of autoantibodies directed against proteins contained in the lysosomal compartments of neutrophils and monocytes. The primary target antigens have been identified as proteinase 3 (Pr3), a 29-kd neutral serine proteinase, and myeloperoxidase (MPO), a 140-kd protein involved in the generation of reactive oxygen species.2 To date, detection of ANCAs has proven to be a helpful diagnostic tool and many clinical studies have confirmed that Pr3-ANCA and MPO-ANCA are highly specific for Wegener's granulomatosis and microscopic polyangiitis, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
3.0
Pr3-ANCA