Relation Results

Summary

Name Pr3-ANCA
Primary ID SIGNOR-C475
Type complex
Formed by
Relations 4

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Type: Score: Layout: SPV 
0.00.20.70.7Pr3-ANCAPRTN3PAMPsNeutrophil_activation

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Relations
Regulator
Mechanism
target
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+ form complex img/form-complex.png binding Pr3-ANCA
Identifier Residue Sequence Organism Cell Line
SIGNOR-270594 Homo sapiens
pmid sentence
Although the majority of PR3-ANCAs are of the IgG isotype, the results of one study showed that PR3-ANCAs of the IgA isotype were present in up to 30% of patients with GPA
Publications: 1 Organism: Homo Sapiens
+ PRTN3up-regulates activity img/direct-activation.png binding Pr3-ANCA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270581 Homo sapiens
pmid sentence
ANCAs comprise a group of autoantibodies directed against proteins contained in the lysosomal compartments of neutrophils and monocytes. The primary target antigens have been identified as proteinase 3 (Pr3), a 29-kd neutral serine proteinase, and myeloperoxidase (MPO), a 140-kd protein involved in the generation of reactive oxygen species.2 To date, detection of ANCAs has proven to be a helpful diagnostic tool and many clinical studies have confirmed that Pr3-ANCA and MPO-ANCA are highly specific for Wegener's granulomatosis and microscopic polyangiitis, respectively
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Serum
+ PAMPsup-regulates quantity img/indirect-activation.png Pr3-ANCA 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270587 Homo sapiens
pmid sentence
In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. |using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus.
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Serum
+ Pr3-ANCAup-regulates img/indirect-activation.png Neutrophil_activation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270584 Homo sapiens
pmid sentence
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation.
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Serum
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